Omega-3 fatty acids in the treatment of peripheral neuropathic pain: new pharmacological strategies
Chronic pain has a marked negative impact on the quality of life. In recent years, it has been increasing interest in the development of new safer more effective treatments of neuropathic pain, which is presented with sensory abnormalities such as allodynia and hyperalgesia. Recent studies ...
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| Autores principales: | , , , , , |
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| Formato: | Artículo revista |
| Lenguaje: | Español |
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Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología
2019
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| Materias: | |
| Acceso en línea: | https://revistas.unc.edu.ar/index.php/med/article/view/25889 |
| Aporte de: |
| Sumario: | Chronic pain has a marked negative impact on the quality of life. In recent years, it has been increasing interest in the development of new safer more effective treatments of neuropathic pain, which is presented with sensory abnormalities such as allodynia and hyperalgesia. Recent studies have demonstrated the analgesic effect of omega-3 fatty acids (O3). The aim of the present work was to evaluate thermal hyperalgesia, mechanical allodynia and nerve regeneration after treatment with O3 in an animal model of peripheral neuropathic pain of chronic sciatic nerve constriction (CCI).
Thermal hyperalgesia, mechanical allodynia and nerve regeneration were evaluated in male Wistar rats, which were administered with: oral O3 (0.32 or 0.72 g / kg) 24 h after ICC and for 21 days (chronic treatment ), oral saline (control group with ICC), local O3 (10 μl, O3 30%) on the sciatic nerve at the end of tissue constriction (acute treatment) and oral O3 (0.32 or 0.72 g / kg) 24 h after surgery but without ICC for 21 days. The tests of thermal hyperalgesia (Hot Plate Test), mechanical allodynia (Von Frey Test) and the functional motor recovery test (Walking track analysis) were performed on days 3, 7, 14 and 21 post-surgery. In all groups, a neuropathological examination was performed on day 21 post-surgery with or without CCI.
Oral O3 treatment blocked of thermal hyperalgesia, decreased the mechanical allodynia (50%) and allowed for the motor function recovery (100%). In addition, neuropathological examination revealed that the nerves conserved the axonal density and architecture while the CCI control group showed loss of continuity of perineurium, neuroma formation and abundant inflammatory infiltrate. In contrast, local O3 administration failed to modify the parameters tested
Oral administration of O3 relieves thermal hyperalgesia effectively and improves the recovery process in rats with CCI, suggesting that they could constitute a potential treatment for the relief of neuropathic pain in humans, with minimal risk of adverse effects. |
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