Characteristics of bloodstream infections in adult patients of two third level centers of Córdoba, Argentina

Background: Bloodstream infections (BI) are associated with high morbidity and mortality. Objetive: To determine epidemiological, microbiological and clinical features of community (CA-BI) and nosocomial bloodstream infections (N-BI). Methods: Bacteremia and fungemia events were retrospectively anal...

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Autores principales: Saad, Emanuel José, Baenas, Diego Federico, Boisseau, Cecilia Soledad, García, Mercedes Jesús, Nuñez, Silvana Alejandra, Balderramo, Domingo Cesar, Hernandez, Daniela, Caeiro, Juan Pablo
Formato: Artículo revista
Lenguaje:Español
Publicado: Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología 2018
Materias:
adultos
bacteriemia
epidemiología
antiinfecciosos
adults
bacteremia
epidemiology
anti-infective agents
Acceso en línea:https://revistas.unc.edu.ar/index.php/med/article/view/19455
Aporte de:
Revista de la Facultad de Ciencias Médicas de Córdoba de Universidad Nacional de Córdoba
id I10-R327-article-19455
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institution Universidad Nacional de Córdoba
institution_str I-10
repository_str R-327
container_title_str Revista de la Facultad de Ciencias Médicas de Córdoba
language Español
format Artículo revista
topic adultos
bacteriemia
epidemiología
antiinfecciosos
adults
bacteremia
epidemiology
anti-infective agents
spellingShingle adultos
bacteriemia
epidemiología
antiinfecciosos
adults
bacteremia
epidemiology
anti-infective agents
Saad, Emanuel José
Baenas, Diego Federico
Boisseau, Cecilia Soledad
García, Mercedes Jesús
Nuñez, Silvana Alejandra
Balderramo, Domingo Cesar
Hernandez, Daniela
Caeiro, Juan Pablo
Characteristics of bloodstream infections in adult patients of two third level centers of Córdoba, Argentina
topic_facet adultos
bacteriemia
epidemiología
antiinfecciosos
adults
bacteremia
epidemiology
anti-infective agents
author Saad, Emanuel José
Baenas, Diego Federico
Boisseau, Cecilia Soledad
García, Mercedes Jesús
Nuñez, Silvana Alejandra
Balderramo, Domingo Cesar
Hernandez, Daniela
Caeiro, Juan Pablo
author_facet Saad, Emanuel José
Baenas, Diego Federico
Boisseau, Cecilia Soledad
García, Mercedes Jesús
Nuñez, Silvana Alejandra
Balderramo, Domingo Cesar
Hernandez, Daniela
Caeiro, Juan Pablo
author_sort Saad, Emanuel José
title Characteristics of bloodstream infections in adult patients of two third level centers of Córdoba, Argentina
title_short Characteristics of bloodstream infections in adult patients of two third level centers of Córdoba, Argentina
title_full Characteristics of bloodstream infections in adult patients of two third level centers of Córdoba, Argentina
title_fullStr Characteristics of bloodstream infections in adult patients of two third level centers of Córdoba, Argentina
title_full_unstemmed Characteristics of bloodstream infections in adult patients of two third level centers of Córdoba, Argentina
title_sort characteristics of bloodstream infections in adult patients of two third level centers of córdoba, argentina
description Background: Bloodstream infections (BI) are associated with high morbidity and mortality. Objetive: To determine epidemiological, microbiological and clinical features of community (CA-BI) and nosocomial bloodstream infections (N-BI). Methods: Bacteremia and fungemia events were retrospectively analyzed in two third-level hospitals between April 2009 and August 2013. Results: We identified 1150 events of bloodstream infections, 53.2% were CA-BI. Gram negative microorganisms were isolated in 61%. The most frequent pathogens were Escherichia coli in CA-BI and Klebsiella pneumoniae in N-BI. Staphylococcus aureus was the most frequent gram positive organism. The main comorbidities were renal disease (39%) and malignancy (38%). There were 26.8% of primary bloodstream infections, and the main infection foci included respiratory (17.04%) and urinary tract (16.86%). A high percentage of gram-negative bacteria of CA-BI and N-BI were resistance to ampicillin sulbactam (40.2% and 57.5%), cephalothin (36.7% and 46.8%), trimethoprim-sulfamethoxazole 32.8% vs 35.5%) and ciprofloxacin (24.6% and 35.3%). Methicillin-resistant Staphylococcus aureus were more frequently into ITS-IH (31.4% vs 11.8%, p = 0.007). Conclusions: Clinical and epidemiological characteristics of CA-BI and N-BI were similar to those reported by other Latin-American studies. We observed some differences in antimicrobial resistance profiles. We emphasize the importance of local epidemiological surveillance to choose appropriate empirical treatments.
publisher Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología
publishDate 2018
url https://revistas.unc.edu.ar/index.php/med/article/view/19455
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spelling I10-R327-article-194552024-08-27T18:21:47Z Characteristics of bloodstream infections in adult patients of two third level centers of Córdoba, Argentina Características de las infecciones del torrente sanguíneo en pacientes adultos de dos centros de tercer nivel de Córdoba, Argentina Saad, Emanuel José Baenas, Diego Federico Boisseau, Cecilia Soledad García, Mercedes Jesús Nuñez, Silvana Alejandra Balderramo, Domingo Cesar Hernandez, Daniela Caeiro, Juan Pablo adultos bacteriemia epidemiología antiinfecciosos adults bacteremia epidemiology anti-infective agents Background: Bloodstream infections (BI) are associated with high morbidity and mortality. Objetive: To determine epidemiological, microbiological and clinical features of community (CA-BI) and nosocomial bloodstream infections (N-BI). Methods: Bacteremia and fungemia events were retrospectively analyzed in two third-level hospitals between April 2009 and August 2013. Results: We identified 1150 events of bloodstream infections, 53.2% were CA-BI. Gram negative microorganisms were isolated in 61%. The most frequent pathogens were Escherichia coli in CA-BI and Klebsiella pneumoniae in N-BI. Staphylococcus aureus was the most frequent gram positive organism. The main comorbidities were renal disease (39%) and malignancy (38%). There were 26.8% of primary bloodstream infections, and the main infection foci included respiratory (17.04%) and urinary tract (16.86%). A high percentage of gram-negative bacteria of CA-BI and N-BI were resistance to ampicillin sulbactam (40.2% and 57.5%), cephalothin (36.7% and 46.8%), trimethoprim-sulfamethoxazole 32.8% vs 35.5%) and ciprofloxacin (24.6% and 35.3%). Methicillin-resistant Staphylococcus aureus were more frequently into ITS-IH (31.4% vs 11.8%, p = 0.007). Conclusions: Clinical and epidemiological characteristics of CA-BI and N-BI were similar to those reported by other Latin-American studies. We observed some differences in antimicrobial resistance profiles. We emphasize the importance of local epidemiological surveillance to choose appropriate empirical treatments. Introducción: Las infecciones del torrente sanguíneo (ITS) generan elevada morbimortalidad. Objetivo: Determinar características epidemiológicas, microbiológicas y clínicas de ITS adquiridas en la comunidad (ITS-AC) e intrahospitalarias (ITS-IH). Métodos: Se analizaron retrospectivamente eventos de bacteriemia y fungemia en dos hospitales de tercer nivel entre abril de 2009 y agosto de 2013.  Resultados: Se identificaron 1150 eventos de ITS, 53% ITS-AC. El 61% de microorganismos aislados fueron gram negativos. Los patógenos más frecuentes fueron Escherichia coli en ITS-AC y Klebsiella pneumoniae en ITS-IH.  Staphylococcus aureus fue el gram positivo más frecuente. Las principales comorbilidades fueron enfermedad renal (39%) y neoplasias (38%). El 26,8% de ITS fueron primarias. Los focos infecciosos más frecuentes fueron respiratorio (17%) y urinario (16,9%). Un elevado porcentaje de gram negativos en ITS-AC e ITS-IH fueron resistentes a ampicilina sulbactam (40,2% y 57,5%), cefalotina (36,7% y 46,8%), trimetoprima-sulfametoxazol (32,8% vs 35,5%) y ciprofloxacina (24,6% y 35,3%). Staphylococcus aureus meticilino resistente fue más frecuente en ITS-IH (31,4% vs 11,8%, p=0,007). Conclusiones: Las características clínicas y epidemiológicas de ITS fueron similares a las reportadas por otros estudios latinoamericanos. Pero observamos algunas diferencias en los perfiles de susceptibilidad antimicrobiana. Resaltamos la importancia de la vigilancia epidemiológica local para elegir tratamientos empíricos apropiados. Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología 2018-09-02 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Estudio retrospectivo application/pdf application/vnd.openxmlformats-officedocument.spreadsheetml.sheet https://revistas.unc.edu.ar/index.php/med/article/view/19455 10.31053/1853.0605.v75.n3.19455 Revista de la Facultad de Ciencias Médicas de Córdoba.; Vol. 75 No. 3 (2018); 156-167 Revista de la Facultad de Ciencias Médicas de Córdoba; Vol. 75 Núm. 3 (2018); 156-167 Revista da Faculdade de Ciências Médicas de Córdoba; v. 75 n. 3 (2018); 156-167 1853-0605 0014-6722 10.31053/1853.0605.v75.n3 spa https://revistas.unc.edu.ar/index.php/med/article/view/19455/20822 https://revistas.unc.edu.ar/index.php/med/article/view/19455/26811 Derechos de autor 2018 Universidad Nacional de Córdoba https://creativecommons.org/licenses/by-nc/4.0

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