IL-6, MMP 3 and prognosis in previously healthy sepsis patients

Sepsis and septic shock are clinical conditions with high mortality despite advances in technology and are the leading cause of death in intensive care. Clinical manifestations and morbidity may be attributable to a disproportionate increase in proinflammatory cytokines. The aim of this study was to...

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Autores principales: Ricarte-Bratti, Juan Pablo, Jaime-Albarrán, Nicolas, Montrull, Hilda Lucrecia, Brizuela, Nilda Yolanda
Formato: Artículo revista
Lenguaje:Inglés
Publicado: Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología 2017
Materias:
Sepsis
Cytokines
Matrix Metalloproteases
Interleukin 6
Prognosis
Mortality
Acceso en línea:https://revistas.unc.edu.ar/index.php/med/article/view/14608
Aporte de:
Revista de la Facultad de Ciencias Médicas de Córdoba de Universidad Nacional de Córdoba
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spelling I10-R327-article-146082024-08-27T18:20:12Z IL-6, MMP 3 and prognosis in previously healthy sepsis patients Ricarte-Bratti, Juan Pablo Jaime-Albarrán, Nicolas Montrull, Hilda Lucrecia Brizuela, Nilda Yolanda Sepsis Cytokines Matrix Metalloproteases Interleukin 6 Prognosis Mortality Sepsis and septic shock are clinical conditions with high mortality despite advances in technology and are the leading cause of death in intensive care. Clinical manifestations and morbidity may be attributable to a disproportionate increase in proinflammatory cytokines. The aim of this study was to evaluate the ability to predict mortality from interleukin 6 [IL-6] and matrix metalloproteinase 3 [MMP-3]. This single-center, observational, prospective study included 48 adult patients admitted to the Hospital Nacional de Clinicas in Cordoba, Argentina, with sepsis or septic shock. Serum levels of IL-6 and MMP-3 were measured at the time of diagnosis and 72 hours later. At time of admission, MMP-3 was 13.77 mg/ml in patients who died and 10.55 mg/ml in patients who survived up to 28 days after hospitalization [p = 0.012], while IL-6 did not differ between the groups. The change in IL-6 over 72 hours was increased in nonsurvivors by 21.11 ± 11.81 pg/ml and decreased in survivors by 40.87 ± 14.94 pg/ml [p = 0.007]. No difference in the change of MMP-3 over 72 hours was observed between survivors and nonsurvivors. This study shows that MMP-3 at admission and the change in IL-6 over the first 72 hours of hospitalization could provide prognostic information in septic patients. Further studies are needed to define the utility of these cytokines as a measure of sepsis severity and as predictors of mortality. Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología 2017-06-07 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf application/msword application/msword image/jpeg image/jpeg image/jpeg image/jpeg application/msword https://revistas.unc.edu.ar/index.php/med/article/view/14608 10.31053/1853.0605.v74.n2.14608 Revista de la Facultad de Ciencias Médicas de Córdoba.; Vol. 74 No. 2 (2017); 99-106 Revista de la Facultad de Ciencias Médicas de Córdoba; Vol. 74 Núm. 2 (2017); 99-106 Revista da Faculdade de Ciências Médicas de Córdoba; v. 74 n. 2 (2017); 99-106 1853-0605 0014-6722 10.31053/1853.0605.v74.n2 eng https://revistas.unc.edu.ar/index.php/med/article/view/14608/16724 https://revistas.unc.edu.ar/index.php/med/article/view/14608/26052 https://revistas.unc.edu.ar/index.php/med/article/view/14608/26053 https://revistas.unc.edu.ar/index.php/med/article/view/14608/26054 https://revistas.unc.edu.ar/index.php/med/article/view/14608/26055 https://revistas.unc.edu.ar/index.php/med/article/view/14608/26056 https://revistas.unc.edu.ar/index.php/med/article/view/14608/26057 https://revistas.unc.edu.ar/index.php/med/article/view/14608/26058 Derechos de autor 2017 Universidad Nacional de Córdoba https://creativecommons.org/licenses/by-nc/4.0
institution Universidad Nacional de Córdoba
institution_str I-10
repository_str R-327
container_title_str Revista de la Facultad de Ciencias Médicas de Córdoba
language Inglés
format Artículo revista
topic Sepsis
Cytokines
Matrix Metalloproteases
Interleukin 6
Prognosis
Mortality
spellingShingle Sepsis
Cytokines
Matrix Metalloproteases
Interleukin 6
Prognosis
Mortality
Ricarte-Bratti, Juan Pablo
Jaime-Albarrán, Nicolas
Montrull, Hilda Lucrecia
Brizuela, Nilda Yolanda
IL-6, MMP 3 and prognosis in previously healthy sepsis patients
topic_facet Sepsis
Cytokines
Matrix Metalloproteases
Interleukin 6
Prognosis
Mortality
author Ricarte-Bratti, Juan Pablo
Jaime-Albarrán, Nicolas
Montrull, Hilda Lucrecia
Brizuela, Nilda Yolanda
author_facet Ricarte-Bratti, Juan Pablo
Jaime-Albarrán, Nicolas
Montrull, Hilda Lucrecia
Brizuela, Nilda Yolanda
author_sort Ricarte-Bratti, Juan Pablo
title IL-6, MMP 3 and prognosis in previously healthy sepsis patients
title_short IL-6, MMP 3 and prognosis in previously healthy sepsis patients
title_full IL-6, MMP 3 and prognosis in previously healthy sepsis patients
title_fullStr IL-6, MMP 3 and prognosis in previously healthy sepsis patients
title_full_unstemmed IL-6, MMP 3 and prognosis in previously healthy sepsis patients
title_sort il-6, mmp 3 and prognosis in previously healthy sepsis patients
description Sepsis and septic shock are clinical conditions with high mortality despite advances in technology and are the leading cause of death in intensive care. Clinical manifestations and morbidity may be attributable to a disproportionate increase in proinflammatory cytokines. The aim of this study was to evaluate the ability to predict mortality from interleukin 6 [IL-6] and matrix metalloproteinase 3 [MMP-3]. This single-center, observational, prospective study included 48 adult patients admitted to the Hospital Nacional de Clinicas in Cordoba, Argentina, with sepsis or septic shock. Serum levels of IL-6 and MMP-3 were measured at the time of diagnosis and 72 hours later. At time of admission, MMP-3 was 13.77 mg/ml in patients who died and 10.55 mg/ml in patients who survived up to 28 days after hospitalization [p = 0.012], while IL-6 did not differ between the groups. The change in IL-6 over 72 hours was increased in nonsurvivors by 21.11 ± 11.81 pg/ml and decreased in survivors by 40.87 ± 14.94 pg/ml [p = 0.007]. No difference in the change of MMP-3 over 72 hours was observed between survivors and nonsurvivors. This study shows that MMP-3 at admission and the change in IL-6 over the first 72 hours of hospitalization could provide prognostic information in septic patients. Further studies are needed to define the utility of these cytokines as a measure of sepsis severity and as predictors of mortality.
publisher Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología
publishDate 2017
url https://revistas.unc.edu.ar/index.php/med/article/view/14608
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AT montrullhildalucrecia il6mmp3andprognosisinpreviouslyhealthysepsispatients
AT brizuelanildayolanda il6mmp3andprognosisinpreviouslyhealthysepsispatients
first_indexed 2024-09-03T20:58:17Z
last_indexed 2024-09-03T20:58:17Z
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