A systematic review on COVID-19 pandemic with special emphasis on curative potentials of Nigeria based medicinal plants

Despite the frightening mortality rate associated with COVID-19, there is no known approved drug to effectively combat the pandemic. COVID-19 clinical manifestations include fever, fatigue, cough, shortness of breath, and other complications. At present, there is no known effective treatment or vacc...

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Autores principales: Oladele, Johnson O., Ajayi, Ebenezer Idowu O., Oyeleke, Oyedotun M., Oladele, Oluwaseun T., Olowookere, Boyede D., Adeniyi, Boluwaji M., Oyewole, Olu I., Oladiji, Adenike T.
Formato: article
Lenguaje:Inglés
Publicado: 2021
Materias:
SARS-CoV-2
Antivirals
COVID-19
Phytochemicals
Coronavirus
Medicinal plants
Biochemistry
Epidemiology
Food science
Health sciences
Pathophysiology
Toxicology
Phytochemistry
Evidence based medicine
Acceso en línea:http://hdl.handle.net/11086/19894
https://www.cell.com/heliyon/fulltext/S2405-8440(20)31740-0?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS2405844020317400%3Fshowall%3Dtrue
Aporte de:
Repositorio Digital Universitario (UNC) de Universidad Nacional de Córdoba
id I10-R14111086-19894
record_format dspace
institution Universidad Nacional de Córdoba
institution_str I-10
repository_str R-141
collection Repositorio Digital Universitario (UNC)
language Inglés
topic SARS-CoV-2
Antivirals
COVID-19
Phytochemicals
Coronavirus
Medicinal plants
Biochemistry
Epidemiology
Food science
Health sciences
Pathophysiology
Toxicology
Phytochemistry
Evidence based medicine
spellingShingle SARS-CoV-2
Antivirals
COVID-19
Phytochemicals
Coronavirus
Medicinal plants
Biochemistry
Epidemiology
Food science
Health sciences
Pathophysiology
Toxicology
Phytochemistry
Evidence based medicine
Oladele, Johnson O.
Ajayi, Ebenezer Idowu O.
Oyeleke, Oyedotun M.
Oladele, Oluwaseun T.
Olowookere, Boyede D.
Adeniyi, Boluwaji M.
Oyewole, Olu I.
Oladiji, Adenike T.
A systematic review on COVID-19 pandemic with special emphasis on curative potentials of Nigeria based medicinal plants
topic_facet SARS-CoV-2
Antivirals
COVID-19
Phytochemicals
Coronavirus
Medicinal plants
Biochemistry
Epidemiology
Food science
Health sciences
Pathophysiology
Toxicology
Phytochemistry
Evidence based medicine
description Despite the frightening mortality rate associated with COVID-19, there is no known approved drug to effectively combat the pandemic. COVID-19 clinical manifestations include fever, fatigue, cough, shortness of breath, and other complications. At present, there is no known effective treatment or vaccine that can mitigate/inhibit SARS-CoV-2. Available clinical intervention for COVID-19 is only palliative and limited to support. Thus, there is an exigent need for effective and non-invasive treatment. This article evaluates the possible mechanism of actions of SARS-CoV-2 and present Nigeria based medicinal plants which have pharmacological and biological activities that can mitigate the hallmarks of the pathogenesis of COVID-19. SARS-CoV-2 mode of actions includes hyper-inflammation characterized by a severe and fatal hyper-cytokinaemia with multi-organ failure; immunosuppression; reduction of angiotensin-converting enzyme 2 (ACE2) to enhance pulmonary vascular permeability causing damage to the alveoli; and further activated by open reading frame (ORF)3a, ORF3b, and ORF7a via c-Jun N- terminal kinase (JNK) pathway which induces lung damage. These mechanisms of action of SARS-CoV-2 can be mitigated by a combination therapy of medicinal herbs based on their pharmacological activities. Since the clinical manifestations of COVID-19 are multifactorial with co-morbidities, we strongly recommend the use of combined therapy such that two or more herbs with specific therapeutic actions are administered to combat the mediators of the disease.
format article
author Oladele, Johnson O.
Ajayi, Ebenezer Idowu O.
Oyeleke, Oyedotun M.
Oladele, Oluwaseun T.
Olowookere, Boyede D.
Adeniyi, Boluwaji M.
Oyewole, Olu I.
Oladiji, Adenike T.
author_facet Oladele, Johnson O.
Ajayi, Ebenezer Idowu O.
Oyeleke, Oyedotun M.
Oladele, Oluwaseun T.
Olowookere, Boyede D.
Adeniyi, Boluwaji M.
Oyewole, Olu I.
Oladiji, Adenike T.
author_sort Oladele, Johnson O.
title A systematic review on COVID-19 pandemic with special emphasis on curative potentials of Nigeria based medicinal plants
title_short A systematic review on COVID-19 pandemic with special emphasis on curative potentials of Nigeria based medicinal plants
title_full A systematic review on COVID-19 pandemic with special emphasis on curative potentials of Nigeria based medicinal plants
title_fullStr A systematic review on COVID-19 pandemic with special emphasis on curative potentials of Nigeria based medicinal plants
title_full_unstemmed A systematic review on COVID-19 pandemic with special emphasis on curative potentials of Nigeria based medicinal plants
title_sort systematic review on covid-19 pandemic with special emphasis on curative potentials of nigeria based medicinal plants
publishDate 2021
url http://hdl.handle.net/11086/19894
https://www.cell.com/heliyon/fulltext/S2405-8440(20)31740-0?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS2405844020317400%3Fshowall%3Dtrue
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