Effect of haloperidol on consummatory successive positive contrast in adult rats with adolescent isolation

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Rats exposed to adolescent isolation (AA) show neurological and behavioral disorders into adulthood, many of them related to changes in response to appetitive reinforcers. Previous studies showed an increase of consummatory Successive Positive Contrast(cSPC, i.e., increased consumption of 32% sugar...

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Autores principales: Cuenya, Lucas, Serafini, Matías, Mustaca, Alba, Kamenetzky, Giselle
Formato: Artículo revista
Lenguaje:Español
Publicado: Universidad Nacional de Córdoba 2015
Materias:
adolescent isolation
positive contrast
haloperidol
dopamine
rat
aislamiento adolescente
contraste positivo
dopamina
rata
Acceso en línea:https://revistas.unc.edu.ar/index.php/racc/article/view/9482
Aporte de:
Revistas de la UNC de Universidad Nacional de Córdoba
id I10-R10article-9482
record_format ojs
institution Universidad Nacional de Córdoba
institution_str I-10
repository_str R-10
container_title_str Revistas de la UNC
language Español
format Artículo revista
topic adolescent isolation
positive contrast
haloperidol
dopamine
rat
aislamiento adolescente
contraste positivo
haloperidol
dopamina
rata
spellingShingle adolescent isolation
positive contrast
haloperidol
dopamine
rat
aislamiento adolescente
contraste positivo
haloperidol
dopamina
rata
Cuenya, Lucas
Serafini, Matías
Mustaca, Alba
Kamenetzky, Giselle
Effect of haloperidol on consummatory successive positive contrast in adult rats with adolescent isolation
topic_facet adolescent isolation
positive contrast
haloperidol
dopamine
rat
aislamiento adolescente
contraste positivo
haloperidol
dopamina
rata
author Cuenya, Lucas
Serafini, Matías
Mustaca, Alba
Kamenetzky, Giselle
author_facet Cuenya, Lucas
Serafini, Matías
Mustaca, Alba
Kamenetzky, Giselle
author_sort Cuenya, Lucas
title Effect of haloperidol on consummatory successive positive contrast in adult rats with adolescent isolation
title_short Effect of haloperidol on consummatory successive positive contrast in adult rats with adolescent isolation
title_full Effect of haloperidol on consummatory successive positive contrast in adult rats with adolescent isolation
title_fullStr Effect of haloperidol on consummatory successive positive contrast in adult rats with adolescent isolation
title_full_unstemmed Effect of haloperidol on consummatory successive positive contrast in adult rats with adolescent isolation
title_sort effect of haloperidol on consummatory successive positive contrast in adult rats with adolescent isolation
description Rats exposed to adolescent isolation (AA) show neurological and behavioral disorders into adulthood, many of them related to changes in response to appetitive reinforcers. Previous studies showed an increase of consummatory Successive Positive Contrast(cSPC, i.e., increased consumption of 32% sugar solution, 24 hours after having access to 4% solution) in rats exposed to AA, in comparison to animals without AA. This study aim at evaluating whether this effect is associated with dopaminergic hyperactivity. Haloperidol (0.1 mg / kg, i.p.) was administered before animals with AA were exposed to the presentation of the increased solution (4% to 32%), while saline was administered to the control group. cSPC effect was not observed in animals receiving haloperidol, while a one trial positive contrast was expressed in animals receiving saline. These results confirm the proposed hypothesis. Although the results are promising, further experiments are needed to determine more precisely the neurochemical correlate of increased cSPC in animals with AA.
publisher Universidad Nacional de Córdoba
publishDate 2015
url https://revistas.unc.edu.ar/index.php/racc/article/view/9482
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