¿Can chronic consumption of high fat diet affect the reproductive physiology of offspring?
A high fat diet is an appropriate reflection of the eating habits of Western society. Its consumption during critical stages, such as pregnancy and lactation, can alter the organogenesis in the offspring, making it more susceptible to certain diseases in adulthood. However, it is interesting to know...
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| Autores principales: | , , , , , , |
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| Formato: | Artículo revista |
| Lenguaje: | Español |
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Universidad Nacional Cba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología
2019
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| Acceso en línea: | https://revistas.unc.edu.ar/index.php/med/article/view/25893 |
| Aporte de: |
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I10-R10article-25893 |
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ojs |
| institution |
Universidad Nacional de Córdoba |
| institution_str |
I-10 |
| repository_str |
R-10 |
| container_title_str |
Revistas de la UNC |
| language |
Español |
| format |
Artículo revista |
| topic |
nutrition high fat diet reproduction puberty estrous cycle nutrición dieta hipergrasa reproducción pubertad ciclo estral. |
| spellingShingle |
nutrition high fat diet reproduction puberty estrous cycle nutrición dieta hipergrasa reproducción pubertad ciclo estral. Degiovanni, A Libovich, MD Santillán, ME Bianconi, S Avendaño, C Torres, PJ Vicentini, LM ¿Can chronic consumption of high fat diet affect the reproductive physiology of offspring? |
| topic_facet |
nutrition high fat diet reproduction puberty estrous cycle nutrición dieta hipergrasa reproducción pubertad ciclo estral. |
| author |
Degiovanni, A Libovich, MD Santillán, ME Bianconi, S Avendaño, C Torres, PJ Vicentini, LM |
| author_facet |
Degiovanni, A Libovich, MD Santillán, ME Bianconi, S Avendaño, C Torres, PJ Vicentini, LM |
| author_sort |
Degiovanni, A |
| title |
¿Can chronic consumption of high fat diet affect the reproductive physiology of offspring? |
| title_short |
¿Can chronic consumption of high fat diet affect the reproductive physiology of offspring? |
| title_full |
¿Can chronic consumption of high fat diet affect the reproductive physiology of offspring? |
| title_fullStr |
¿Can chronic consumption of high fat diet affect the reproductive physiology of offspring? |
| title_full_unstemmed |
¿Can chronic consumption of high fat diet affect the reproductive physiology of offspring? |
| title_sort |
¿can chronic consumption of high fat diet affect the reproductive physiology of offspring? |
| description |
A high fat diet is an appropriate reflection of the eating habits of Western society. Its consumption during critical stages, such as pregnancy and lactation, can alter the organogenesis in the offspring, making it more susceptible to certain diseases in adulthood. However, it is interesting to know if its intake in stages prior to conception could have similar effects. The aim of the present work was to analyze the consequences of maternal consumption of a high fat diet prior to fertilization, on morphometric and reproductive parameters of their own and their descendants.
Female Albino swiss mice (n = 36) were fed a high fat diet (HF-24% porcine fat, 24% protein, 41% carbohydrates) or control (C-3.9% fat, 18% protein, 42% carbohydrates), for 10 weeks prior to the onset of pregnancy; all consumed diet C during pregnancy and lactation, as did the offspring from weaning. In mothers: body weight (BW) during treatment, pregnancy and lactation was evaluated; litter size and weight. In the descendants: BW (birth-adulthood); onset of pregnancy (vaginal opening or testicular descent); characteristics of estrous cycles; sperm quality.
In mothers the BW of the HF was significantly higher than that of the C, from day 28 until the end of treatment (day 70: 31.58 ± 0.72 g and 28.22 ± 0.34 g, respectively; p <0.05). The size and weight of the litters was not modified by the HF diet. The BW was significantly higher in female HF pups than in C, from day 21 postnatal to adulthood (p <0.05); in males it was not modified. HF females presented more extensive estrous than their controls (1.86 ± 0.09 and 1.38 ± 0.06 days, respectively; p <0.05) and HF males reached puberty before C (postnatal day 25: 75.00 ± 12% and 25.00 ± 9.13%, respectively; p <0.05). The sperm quality was not significantly modified.
Chronic consumption of the HF diet caused significant weight gain in females, but did not affect their reproductive capacity. Their female offspring had higher BW from puberty to adulthood, while males were not affected. However, in both sexes there were changes in reproductive parameters, possibly associated with maternal nutritional status prior to conception. |
| publisher |
Universidad Nacional Cba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología |
| publishDate |
2019 |
| url |
https://revistas.unc.edu.ar/index.php/med/article/view/25893 |
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