Effect of maternal α-lipoic acid intake on the liver’s antioxidant capacity of ovariectomized female offspring
Lipoic Acid (LA) is an antioxidant that reaches fetal circulation after maternal oral intake. The anti-obesogenic properties of LA are given by a modification of genes related with metabolism and energy expenditure. Furthermore, the fetal period is characterized by strong changes in the expression o...
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Formato: | Artículo revista |
Lenguaje: | Español |
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Universidad Nacional Cba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología
2019
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Acceso en línea: | https://revistas.unc.edu.ar/index.php/med/article/view/25784 |
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institution |
Universidad Nacional de Córdoba |
institution_str |
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Revistas de la UNC |
language |
Español |
format |
Artículo revista |
topic |
lipoic acid metabolic syndrome fetal programming antioxidant ácido lipoico síndrome metabólico programación fetal antioxidante |
spellingShingle |
lipoic acid metabolic syndrome fetal programming antioxidant ácido lipoico síndrome metabólico programación fetal antioxidante Hernández Garrigó, P Elizondo, S Lagares, C Moreira Espinoza, MJ Rabaglino, MB Effect of maternal α-lipoic acid intake on the liver’s antioxidant capacity of ovariectomized female offspring |
topic_facet |
lipoic acid metabolic syndrome fetal programming antioxidant ácido lipoico síndrome metabólico programación fetal antioxidante |
author |
Hernández Garrigó, P Elizondo, S Lagares, C Moreira Espinoza, MJ Rabaglino, MB |
author_facet |
Hernández Garrigó, P Elizondo, S Lagares, C Moreira Espinoza, MJ Rabaglino, MB |
author_sort |
Hernández Garrigó, P |
title |
Effect of maternal α-lipoic acid intake on the liver’s antioxidant capacity of ovariectomized female offspring |
title_short |
Effect of maternal α-lipoic acid intake on the liver’s antioxidant capacity of ovariectomized female offspring |
title_full |
Effect of maternal α-lipoic acid intake on the liver’s antioxidant capacity of ovariectomized female offspring |
title_fullStr |
Effect of maternal α-lipoic acid intake on the liver’s antioxidant capacity of ovariectomized female offspring |
title_full_unstemmed |
Effect of maternal α-lipoic acid intake on the liver’s antioxidant capacity of ovariectomized female offspring |
title_sort |
effect of maternal α-lipoic acid intake on the liver’s antioxidant capacity of ovariectomized female offspring |
description |
Lipoic Acid (LA) is an antioxidant that reaches fetal circulation after maternal oral intake. The anti-obesogenic properties of LA are given by a modification of genes related with metabolism and energy expenditure. Furthermore, the fetal period is characterized by strong changes in the expression of genes that, if altered they can influence the organism fenotype in the postnatal life. The aim of the present work was to assess the effect of maternal intake of AL on gene expression related to the anti-oxidant activity and regulation of fatty acids in the liver of ovariectomized rat offspring.
Pregnant Wistar rats were fed ad-libitum with standard diet (food) + LA (0.4% wt/wt) from day 14 of gestation to day 20 of lactation (L, n=4) or food (C, n=4) as control. Litter size was reduced to 3 females after birth. At 8 months of age, female offsprings were randomly assigned to be ovariectomized (OV) or to receive a sham surgery (SH); resulting in 4 groups: LOV, LSH, COV and CSH (n=5/group). Animals were euthanized after two months for samples’ collection. Expressions of hepatic genes involved in sterol synthesis (Srebf1), oxidation of fatty acids (Cpt1a) and antioxidant enzymes (Cat and Sod1) were measured through qRT-PCR. Results were analyzed by ANOVA and significance was set at p<0.05.
Compared to CSH group, the expression of Srebt1 was higher in COV group; Cpt1a and Sod1 were higher in LSH group and Cat was higher in LOV and LSH group.
Expression of liver genes involved in sterol synthesis, oxidation of fatty acids and antioxidant enzymes were modified by the maternal intake of LA, possibly due to the effect of fetal programming. Therefore, the maternal intake of LA improves the oxidative state of the offspring liver, even when it can be affected by the deficiency of estrogen induced by ovariectomy |
publisher |
Universidad Nacional Cba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología |
publishDate |
2019 |
url |
https://revistas.unc.edu.ar/index.php/med/article/view/25784 |
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