Clinical usefulness of the reticulocyte hemoglobin in chronic hemodialysis patients

Mostrar todas las versiones(2)

Background. Iron deficiency is the main cause of failure to respond to erythropoietin (EPO) in haemodialysis patients. Several laboratory tests to detect the deficiency, ferritin and transferrin saturation (TSat) are the most commonly used but its limitations in this patient population are necessary...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Eckhardt, Andrea, Freiberg, M., De la Fuente, Jorge Luis, Douthat, Walter G., Capra, Raúl Horacio
Formato:	Artículo revista
Lenguaje:	Español
Publicado:	Universidad Nacional Cba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología 2011
Materias:	deficiencia de hierro hemoglobina reticulocitaria equivalente hemodiálisis eritropoyetina saturación de transferrina iron deficiency reticulocyte hemoglobin equivalent haemodialysis erythropoietin transferring saturation
Acceso en línea:	https://revistas.unc.edu.ar/index.php/med/article/view/21535
Aporte de:	Revistas de la UNC de Universidad Nacional de Córdoba

id	I10-R10article-21535
record_format	ojs
institution	Universidad Nacional de Córdoba
institution_str	I-10
repository_str	R-10
container_title_str	Revistas de la UNC
language	Español
format	Artículo revista
topic	deficiencia de hierro hemoglobina reticulocitaria equivalente hemodiálisis eritropoyetina saturación de transferrina iron deficiency reticulocyte hemoglobin equivalent haemodialysis erythropoietin transferring saturation
spellingShingle	deficiencia de hierro hemoglobina reticulocitaria equivalente hemodiálisis eritropoyetina saturación de transferrina iron deficiency reticulocyte hemoglobin equivalent haemodialysis erythropoietin transferring saturation Eckhardt, Andrea Freiberg, M. De la Fuente, Jorge Luis Douthat, Walter G. Capra, Raúl Horacio Clinical usefulness of the reticulocyte hemoglobin in chronic hemodialysis patients
topic_facet	deficiencia de hierro hemoglobina reticulocitaria equivalente hemodiálisis eritropoyetina saturación de transferrina iron deficiency reticulocyte hemoglobin equivalent haemodialysis erythropoietin transferring saturation
author	Eckhardt, Andrea Freiberg, M. De la Fuente, Jorge Luis Douthat, Walter G. Capra, Raúl Horacio
author_facet	Eckhardt, Andrea Freiberg, M. De la Fuente, Jorge Luis Douthat, Walter G. Capra, Raúl Horacio
author_sort	Eckhardt, Andrea
title	Clinical usefulness of the reticulocyte hemoglobin in chronic hemodialysis patients
title_short	Clinical usefulness of the reticulocyte hemoglobin in chronic hemodialysis patients
title_full	Clinical usefulness of the reticulocyte hemoglobin in chronic hemodialysis patients
title_fullStr	Clinical usefulness of the reticulocyte hemoglobin in chronic hemodialysis patients
title_full_unstemmed	Clinical usefulness of the reticulocyte hemoglobin in chronic hemodialysis patients
title_sort	clinical usefulness of the reticulocyte hemoglobin in chronic hemodialysis patients
description	Background. Iron deficiency is the main cause of failure to respond to erythropoietin (EPO) in haemodialysis patients. Several laboratory tests to detect the deficiency, ferritin and transferrin saturation (TSat) are the most commonly used but its limitations in this patient population are necessary to find other parameters to improve the identification of iron-deficient state. Objective. To evaluate the ability of Reticulocyte Hemoglobin Equivalent (RET-He) to predict iron deficiency, taking as a reference standard to the increase of hemoglobin in response to iron intake. Materials and Methods. 44 patients on chronic hemodialysis and fixed-dose EPO received 400 mg of intravenous iron. Were measured Hb, Ret-He, IRF, and ferritin prior to iron administration. After 20 to 30 days of completion of loading the patients were classified as responders if hemoglobin increased by at least 0.8 g / L and non-responders if this increase did not occur. Result. 25 patients were reponders, the ROC curves analysis showed the Ret-He with the largest AUC of 0.862 similar to the AUC of 0.833 that showed the IST, but the first is more sensitive (72% CI 95%: 51-88% vs 52% 95% CI 31-72%) and similar specificity (94.7% CI 95%: 74-100% vs 100% 95% CI 82-100%). Ferritin AUC was 0.772 and finally the IRF AUC was 0.7. The Ret-He, to a cutoff of 29.5 pg was the best combination of sensitivity and specificity (72 and 94.7 respectively), and the sensitivity of the combination Ret-He/IST rose to 80% specificity 94.7%. Conclusions. According to these results it could consider to Ret-He and the Ret-He/IST combination of clinical utility for the identification of the iron deficit in patients in chronic haemodialysis.
publisher	Universidad Nacional Cba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología
publishDate	2011
url	https://revistas.unc.edu.ar/index.php/med/article/view/21535
work_keys_str_mv	AT eckhardtandrea clinicalusefulnessofthereticulocytehemoglobininchronichemodialysispatients AT freibergm clinicalusefulnessofthereticulocytehemoglobininchronichemodialysispatients AT delafuentejorgeluis clinicalusefulnessofthereticulocytehemoglobininchronichemodialysispatients AT douthatwalterg clinicalusefulnessofthereticulocytehemoglobininchronichemodialysispatients AT capraraulhoracio clinicalusefulnessofthereticulocytehemoglobininchronichemodialysispatients AT eckhardtandrea utilidadclinicadelahemoglobinareticulocitariaequivalenteenpacientesenhemodialisiscronica AT freibergm utilidadclinicadelahemoglobinareticulocitariaequivalenteenpacientesenhemodialisiscronica AT delafuentejorgeluis utilidadclinicadelahemoglobinareticulocitariaequivalenteenpacientesenhemodialisiscronica AT douthatwalterg utilidadclinicadelahemoglobinareticulocitariaequivalenteenpacientesenhemodialisiscronica AT capraraulhoracio utilidadclinicadelahemoglobinareticulocitariaequivalenteenpacientesenhemodialisiscronica
bdutipo_str	Revistas
_version_	1764819782143574016

Clinical usefulness of the reticulocyte hemoglobin in chronic hemodialysis patients

Ejemplares similares