Positive correlation between proteasome activity and polyphenols in the telencephalon of adult female mice
Introduction: Proteasome regulates proteostasis, and can be compromised in neurodegenerative diseases. Thus, our aim was to correlate the activity of proteasome to the level of polyphenols in telencephalon during murine adulthood. Methods: Proteasome activity, polyphenols and other variables (glucos...
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Formato: | Artículo revista |
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Universidad Nacional Cba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología
2018
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Acceso en línea: | https://revistas.unc.edu.ar/index.php/med/article/view/19930 |
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I10-R10article-19930 |
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Universidad Nacional de Córdoba |
institution_str |
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R-10 |
container_title_str |
Revistas de la UNC |
language |
Inglés |
format |
Artículo revista |
topic |
central nervous system aging proteostasis phytochemicals multivariate statistics sistema nervioso central envejecimiento proteostasis fitoquímicos estadística multivariada. |
spellingShingle |
central nervous system aging proteostasis phytochemicals multivariate statistics sistema nervioso central envejecimiento proteostasis fitoquímicos estadística multivariada. Miranda, Agustín Ramiro Cortez, Mariela Valentina Serra, Silvana Valeria Soria, Elio Andres Positive correlation between proteasome activity and polyphenols in the telencephalon of adult female mice |
topic_facet |
central nervous system aging proteostasis phytochemicals multivariate statistics sistema nervioso central envejecimiento proteostasis fitoquímicos estadística multivariada. |
author |
Miranda, Agustín Ramiro Cortez, Mariela Valentina Serra, Silvana Valeria Soria, Elio Andres |
author_facet |
Miranda, Agustín Ramiro Cortez, Mariela Valentina Serra, Silvana Valeria Soria, Elio Andres |
author_sort |
Miranda, Agustín Ramiro |
title |
Positive correlation between proteasome activity and polyphenols in the telencephalon of adult female mice |
title_short |
Positive correlation between proteasome activity and polyphenols in the telencephalon of adult female mice |
title_full |
Positive correlation between proteasome activity and polyphenols in the telencephalon of adult female mice |
title_fullStr |
Positive correlation between proteasome activity and polyphenols in the telencephalon of adult female mice |
title_full_unstemmed |
Positive correlation between proteasome activity and polyphenols in the telencephalon of adult female mice |
title_sort |
positive correlation between proteasome activity and polyphenols in the telencephalon of adult female mice |
description |
Introduction: Proteasome regulates proteostasis, and can be compromised in neurodegenerative diseases. Thus, our aim was to correlate the activity of proteasome to the level of polyphenols in telencephalon during murine adulthood. Methods: Proteasome activity, polyphenols and other variables (glucose and hydroperoxides) were analysed in Balb/c female telencephala (n = 20, age = 4-12 months), using multivariate methods. Results: The following values were found: proteasome activity = 3.1 ± 0.6 FI/µg of tissue proteins, glucose = 0.1 ± 0.0 µg/µg, hydroperoxides = 363.4 ± 96.6 OD/µg, and polyphenols = 0.1 ± 0.0 ng/µg. Polyphenols reduced during aging showed a direct correlation with proteasome (Pearson’s coefficient = 0.43, p = 0.0590, and a multivariate linear regressive coefficient = 17.85, p = 0.0216), with glucose and hydroperoxides being not involved (p>0.1). This correlation was confirmed by partial least square regression (beta = 0.67). Conclusion: Proteasome activity can be affected during ageing, and promoted by telencephalic polyphenol levels. Thus, these diet compounds might exert benefits in adult brain. |
publisher |
Universidad Nacional Cba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología |
publishDate |
2018 |
url |
https://revistas.unc.edu.ar/index.php/med/article/view/19930 |
work_keys_str_mv |
AT mirandaagustinramiro positivecorrelationbetweenproteasomeactivityandpolyphenolsinthetelencephalonofadultfemalemice AT cortezmarielavalentina positivecorrelationbetweenproteasomeactivityandpolyphenolsinthetelencephalonofadultfemalemice AT serrasilvanavaleria positivecorrelationbetweenproteasomeactivityandpolyphenolsinthetelencephalonofadultfemalemice AT soriaelioandres positivecorrelationbetweenproteasomeactivityandpolyphenolsinthetelencephalonofadultfemalemice AT mirandaagustinramiro correlacionpositivaentrelaactividadproteasomalylospolifenoleseneltelencefaloderatoneshembrasadultas AT cortezmarielavalentina correlacionpositivaentrelaactividadproteasomalylospolifenoleseneltelencefaloderatoneshembrasadultas AT serrasilvanavaleria correlacionpositivaentrelaactividadproteasomalylospolifenoleseneltelencefaloderatoneshembrasadultas AT soriaelioandres correlacionpositivaentrelaactividadproteasomalylospolifenoleseneltelencefaloderatoneshembrasadultas |
bdutipo_str |
Revistas |
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1764819781217681408 |