Evaluation of equations using cystatin C for estimation of the glomerular filtration rate in healthy adult population of canidates for kidney donors.

Mostrar todas las versiones(2)

The determination of the glomerular filtration rate (GFR) is critical for the selection of potential kidney donors. Methods of measurement of GFR are impractical and complex, which led to development of equations to estimate GFR. Objective: To evaluate of the performance of Creatinine and Cystatin C...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autor principal: Medina Arnaudo, Gisel Ivana
Formato: Artículo revista
Lenguaje:Español
Publicado: Universidad Nacional Cba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología 2017
Materias:
cistatina C
estimación del Índice de Filtrado Glomerular
donantes renales
cystatin C
estimation of Glomerular Filtration Rate
kidney donors
Acceso en línea:https://revistas.unc.edu.ar/index.php/med/article/view/14814
Aporte de:
Revistas de la UNC de Universidad Nacional de Córdoba
id I10-R10article-14814
record_format ojs
institution Universidad Nacional de Córdoba
institution_str I-10
repository_str R-10
container_title_str Revistas de la UNC
language Español
format Artículo revista
topic cistatina C
estimación del Índice de Filtrado Glomerular
donantes renales
cystatin C
estimation of Glomerular Filtration Rate
kidney donors
spellingShingle cistatina C
estimación del Índice de Filtrado Glomerular
donantes renales
cystatin C
estimation of Glomerular Filtration Rate
kidney donors
Medina Arnaudo, Gisel Ivana
Evaluation of equations using cystatin C for estimation of the glomerular filtration rate in healthy adult population of canidates for kidney donors.
topic_facet cistatina C
estimación del Índice de Filtrado Glomerular
donantes renales
cystatin C
estimation of Glomerular Filtration Rate
kidney donors
author Medina Arnaudo, Gisel Ivana
author_facet Medina Arnaudo, Gisel Ivana
author_sort Medina Arnaudo, Gisel Ivana
title Evaluation of equations using cystatin C for estimation of the glomerular filtration rate in healthy adult population of canidates for kidney donors.
title_short Evaluation of equations using cystatin C for estimation of the glomerular filtration rate in healthy adult population of canidates for kidney donors.
title_full Evaluation of equations using cystatin C for estimation of the glomerular filtration rate in healthy adult population of canidates for kidney donors.
title_fullStr Evaluation of equations using cystatin C for estimation of the glomerular filtration rate in healthy adult population of canidates for kidney donors.
title_full_unstemmed Evaluation of equations using cystatin C for estimation of the glomerular filtration rate in healthy adult population of canidates for kidney donors.
title_sort evaluation of equations using cystatin c for estimation of the glomerular filtration rate in healthy adult population of canidates for kidney donors.
description The determination of the glomerular filtration rate (GFR) is critical for the selection of potential kidney donors. Methods of measurement of GFR are impractical and complex, which led to development of equations to estimate GFR. Objective: To evaluate of the performance of Creatinine and Cystatin C based equation for estimation of GFR in healthy adult population of candidates for kidney donors. Materials and Methods: a cross-sectional study was performed in 72 adult patients evaluated as candidates for kidney donors. GFR was measured by nonradiolabeled Iothalamate clearence (mGFR). GFR was estimated by the Modification of Diet in Renal Disease (eGFR MDRD) equation, Chronic Kidney Disease Epidemiology Collaboration study (eGFR CKD-EPICREAT, eGFR CKD-EPI-CREAT+CYSC) and the equation proposed by Stevens et al. (STEVENSCREAT+CYSC). The overall performance of all equations was analyzed. Results: eGFR CKD-EPICREAT+CYSC, eGFR STEVENS CREAT+CYSC and eGFR CKD-EPI-CREAT presented lower bias (1,93; - 0,71; -1,53 mL/ min/1,73m2 respectively) compared with eGFR MDRD (bias= -10,36 mL/min/1.73m2). This study demonstrated that the best diagnostic performance was shown by eGFR CKD-EPICREAT+CYSC (LR(+)=9,8; “Positive Likelihood Ratios”), followed by eGFR STEVENSCREAT+CYSC (LR(+)=4,7) and eGFR CKD-EPICREAT (LR(+)=3,7). Discussion: CKD-EPICREAT+CYSC, STEVENS-CREAT+CYSC and CKDEPI-CREAT equations demonstrated a clearly higher performance to estimate GFR compared with MDRD in the study population.
publisher Universidad Nacional Cba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología
publishDate 2017
url https://revistas.unc.edu.ar/index.php/med/article/view/14814
work_keys_str_mv AT medinaarnaudogiselivana evaluationofequationsusingcystatincforestimationoftheglomerularfiltrationrateinhealthyadultpopulationofcanidatesforkidneydonors
AT medinaarnaudogiselivana evaluaciondeecuacionesqueutilizancistatinacparaestimarfiltradoglomerularenadultossanoscandidatosadonantesrenales
bdutipo_str Revistas
_version_ 1764819781686394880

Ejemplares similares