Effect of haloperidol on consummatory successive positive contrast in adult rats with adolescent isolation

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Rats exposed to adolescent isolation (AA) show neurological and behavioral disorders into adulthood, many of them related to changes in response to appetitive reinforcers. Previous studies showed an increase of consummatory Successive Positive Contrast(cSPC, i.e., increased consumption of 32% sugar...

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Autores principales: Cuenya, Lucas, Serafini, Matías, Mustaca, Alba, Kamenetzky, Giselle
Formato: Artículo revista
Lenguaje:Español
Publicado: Universidad Nacional de Córdoba 2015
Materias:
adolescent isolation
positive contrast
haloperidol
dopamine
rat
aislamiento adolescente
contraste positivo
dopamina
rata
Acceso en línea:https://revistas.unc.edu.ar/index.php/racc/article/view/9482
Aporte de:
Revistas de la UNC de Universidad Nacional de Córdoba
id I10-R10-article-9482
record_format ojs
spelling I10-R10-article-94822019-05-27T16:14:54Z Effect of haloperidol on consummatory successive positive contrast in adult rats with adolescent isolation Efecto del haloperidol sobre el contraste sucesivo positivo consumatorio en ratas adultas con aislamiento adolescente Cuenya, Lucas Serafini, Matías Mustaca, Alba Kamenetzky, Giselle adolescent isolation positive contrast haloperidol dopamine rat aislamiento adolescente contraste positivo haloperidol dopamina rata Rats exposed to adolescent isolation (AA) show neurological and behavioral disorders into adulthood, many of them related to changes in response to appetitive reinforcers. Previous studies showed an increase of consummatory Successive Positive Contrast(cSPC, i.e., increased consumption of 32% sugar solution, 24 hours after having access to 4% solution) in rats exposed to AA, in comparison to animals without AA. This study aim at evaluating whether this effect is associated with dopaminergic hyperactivity. Haloperidol (0.1 mg / kg, i.p.) was administered before animals with AA were exposed to the presentation of the increased solution (4% to 32%), while saline was administered to the control group. cSPC effect was not observed in animals receiving haloperidol, while a one trial positive contrast was expressed in animals receiving saline. These results confirm the proposed hypothesis. Although the results are promising, further experiments are needed to determine more precisely the neurochemical correlate of increased cSPC in animals with AA. Las ratas expuestas a aislamiento adolescente (AA) muestran alteraciones neurológicas y conductuales en la adultez, muchas de ellas relacionadas con cambios en la respuesta ante reforzadores apetitivos. En estudios previos las ratas con AA mostraron un incremento del Contraste Sucesivo Positivo consumatorio(CSPc, i.e, mayor consumo de una solución azucarada al 32%, 24 hs después de tener acceso a una solución al 4%), respecto de animales sin AA. El objetivo de este estudio fue evaluar si este efecto está asociado a la hiperactividad dopaminérgica. Se administró haloperidol a animales con AA (0.1 mg/kg, i.p.) antes de los ensayos de incremento del refuerzo y salina a un grupo control. No se halló CSPc en los animales que recibieron haloperidol, mientras que en los sujetos con salina se observó en un ensayo. Si bien los resultados apoyan la hipótesis propuesta, es necesario realizar futuros experimentos para determinar con mayor precisión el correlato neuroquímico del incremento de CSPc en animales con AA. Universidad Nacional de Córdoba 2015-07-22 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Experimental application/pdf application/msword https://revistas.unc.edu.ar/index.php/racc/article/view/9482 Argentinean Journal of Behavioral Sciences; Vol. 7 No. 2 (2015): Revista Argentina de Ciencias del Comportamiento; 30-37 Revista Argentina de Ciencias del Comportamiento; Vol. 7 Núm. 2 (2015): Revista Argentina de Ciencias del Comportamiento; 30-37 1852-4206 10.32348/1852.4206.v7.n2 spa https://revistas.unc.edu.ar/index.php/racc/article/view/9482/Cuenya%20et%20alpp.30-37 https://revistas.unc.edu.ar/index.php/racc/article/view/9482/25378 Derechos de autor 2015 Lucas Cuenya, Matías Serafini, Alba Mustaca, Giselle Kamenetzky
institution Universidad Nacional de Córdoba
institution_str I-10
repository_str R-10
container_title_str Revistas de la UNC
language Español
format Artículo revista
topic adolescent isolation
positive contrast
haloperidol
dopamine
rat
aislamiento adolescente
contraste positivo
haloperidol
dopamina
rata
spellingShingle adolescent isolation
positive contrast
haloperidol
dopamine
rat
aislamiento adolescente
contraste positivo
haloperidol
dopamina
rata
Cuenya, Lucas
Serafini, Matías
Mustaca, Alba
Kamenetzky, Giselle
Effect of haloperidol on consummatory successive positive contrast in adult rats with adolescent isolation
topic_facet adolescent isolation
positive contrast
haloperidol
dopamine
rat
aislamiento adolescente
contraste positivo
haloperidol
dopamina
rata
author Cuenya, Lucas
Serafini, Matías
Mustaca, Alba
Kamenetzky, Giselle
author_facet Cuenya, Lucas
Serafini, Matías
Mustaca, Alba
Kamenetzky, Giselle
author_sort Cuenya, Lucas
title Effect of haloperidol on consummatory successive positive contrast in adult rats with adolescent isolation
title_short Effect of haloperidol on consummatory successive positive contrast in adult rats with adolescent isolation
title_full Effect of haloperidol on consummatory successive positive contrast in adult rats with adolescent isolation
title_fullStr Effect of haloperidol on consummatory successive positive contrast in adult rats with adolescent isolation
title_full_unstemmed Effect of haloperidol on consummatory successive positive contrast in adult rats with adolescent isolation
title_sort effect of haloperidol on consummatory successive positive contrast in adult rats with adolescent isolation
description Rats exposed to adolescent isolation (AA) show neurological and behavioral disorders into adulthood, many of them related to changes in response to appetitive reinforcers. Previous studies showed an increase of consummatory Successive Positive Contrast(cSPC, i.e., increased consumption of 32% sugar solution, 24 hours after having access to 4% solution) in rats exposed to AA, in comparison to animals without AA. This study aim at evaluating whether this effect is associated with dopaminergic hyperactivity. Haloperidol (0.1 mg / kg, i.p.) was administered before animals with AA were exposed to the presentation of the increased solution (4% to 32%), while saline was administered to the control group. cSPC effect was not observed in animals receiving haloperidol, while a one trial positive contrast was expressed in animals receiving saline. These results confirm the proposed hypothesis. Although the results are promising, further experiments are needed to determine more precisely the neurochemical correlate of increased cSPC in animals with AA.
publisher Universidad Nacional de Córdoba
publishDate 2015
url https://revistas.unc.edu.ar/index.php/racc/article/view/9482
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first_indexed 2022-08-20T00:49:27Z
last_indexed 2022-08-20T00:49:27Z
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