Glomerular function and metabolic syndrome in Venezuelan adults with cardiometabolic risk factors treated in a primary health care center
Introduction: The relationship of the metabolic syndrome (MS) and its components with the reduced glomerular filtration rate and proteinuria is not yet widely elucidated. The aim of the study was to associate the estimated glomerular filtration rate (eGFR) and proteinuria to MS and its individual co...
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| Formato: | Artículo revista |
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Universidad Nacional Cba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología
2019
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| Acceso en línea: | https://revistas.unc.edu.ar/index.php/med/article/view/23677 |
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I10-R10-article-23677 |
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ojs |
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Universidad Nacional de Córdoba |
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Revistas de la UNC |
| language |
Español |
| format |
Artículo revista |
| topic |
metabolic syndrome glomerular filtration rate proteinuria síndrome metabólico tasa de filtración glomerular síndrome metabólica taxa de filtração glomerular proteinúria |
| spellingShingle |
metabolic syndrome glomerular filtration rate proteinuria síndrome metabólico tasa de filtración glomerular síndrome metabólica taxa de filtração glomerular proteinúria Leal, Ulises Ruiz-Fernández, Nelina Alejandra Loaiza, Lisbeth Espinoza, Milagros Glomerular function and metabolic syndrome in Venezuelan adults with cardiometabolic risk factors treated in a primary health care center |
| topic_facet |
metabolic syndrome glomerular filtration rate proteinuria síndrome metabólico tasa de filtración glomerular síndrome metabólica taxa de filtração glomerular proteinúria |
| author |
Leal, Ulises Ruiz-Fernández, Nelina Alejandra Loaiza, Lisbeth Espinoza, Milagros |
| author_facet |
Leal, Ulises Ruiz-Fernández, Nelina Alejandra Loaiza, Lisbeth Espinoza, Milagros |
| author_sort |
Leal, Ulises |
| title |
Glomerular function and metabolic syndrome in Venezuelan adults with cardiometabolic risk factors treated in a primary health care center |
| title_short |
Glomerular function and metabolic syndrome in Venezuelan adults with cardiometabolic risk factors treated in a primary health care center |
| title_full |
Glomerular function and metabolic syndrome in Venezuelan adults with cardiometabolic risk factors treated in a primary health care center |
| title_fullStr |
Glomerular function and metabolic syndrome in Venezuelan adults with cardiometabolic risk factors treated in a primary health care center |
| title_full_unstemmed |
Glomerular function and metabolic syndrome in Venezuelan adults with cardiometabolic risk factors treated in a primary health care center |
| title_sort |
glomerular function and metabolic syndrome in venezuelan adults with cardiometabolic risk factors treated in a primary health care center |
| description |
Introduction: The relationship of the metabolic syndrome (MS) and its components with the reduced glomerular filtration rate and proteinuria is not yet widely elucidated. The aim of the study was to associate the estimated glomerular filtration rate (eGFR) and proteinuria to MS and its individual components in adults with cardiometabolic risk factors, who attended a public health center in the municipality of San Diego, Carabobo State, Venezuela.
Methods: Descriptive and cross-sectional study (n=176 individuals). Weight, height, waist circumference, body fat percentage and blood pressure were measured; serum glucose, creatinine, urea, ureic nitrogen, total cholesterol, low (LDLc) and high (HDLc) density lipoprotein cholesterol, triglycerides and glycosylated hemoglobin A1C in whole blood were determined; the presence of proteinuria was determined in partial urine. The eGFR was estimated by equations and the body mass index (BMI) was calculated.
Results: The frequency of MS was significantly higher among patients with CKD (eGFR < 60 mL/min/m2), mildly reduced eGFR (60-89 mL/min/m2), hyperfiltration or proteinuria. The risks of mildly reduced eGFR and protenuria were significantly associated with elevated fasting blood glucose, low HDLc and MS, with and without adjustment for sex, age and BMI. When adjusted for the diabetic condition, only the risk of proteinuria remained associated with MS and elevated blood pressure. The risk of hyperfiltration was not associated with MS.
Conclusion: The reduction in estimated glomerular function and proteinuria were associated with MS and its individual components. Other studies that confirm the results are required. |
| publisher |
Universidad Nacional Cba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología |
| publishDate |
2019 |
| url |
https://revistas.unc.edu.ar/index.php/med/article/view/23677 |
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I10-R10-article-236772020-02-26T19:07:51Z Glomerular function and metabolic syndrome in Venezuelan adults with cardiometabolic risk factors treated in a primary health care center Función glomerular y síndrome metabólico en adultos venezolanos con factores de riesgo cardiometabólico atendidos en un centro de atención primaria Função glomerular e síndrome metabólica em adultos venezuelanos com fatores de risco cardiometabólicos tratados em um centro de atenção primária Leal, Ulises Ruiz-Fernández, Nelina Alejandra Loaiza, Lisbeth Espinoza, Milagros metabolic syndrome glomerular filtration rate proteinuria síndrome metabólico tasa de filtración glomerular síndrome metabólica taxa de filtração glomerular proteinúria Introduction: The relationship of the metabolic syndrome (MS) and its components with the reduced glomerular filtration rate and proteinuria is not yet widely elucidated. The aim of the study was to associate the estimated glomerular filtration rate (eGFR) and proteinuria to MS and its individual components in adults with cardiometabolic risk factors, who attended a public health center in the municipality of San Diego, Carabobo State, Venezuela. Methods: Descriptive and cross-sectional study (n=176 individuals). Weight, height, waist circumference, body fat percentage and blood pressure were measured; serum glucose, creatinine, urea, ureic nitrogen, total cholesterol, low (LDLc) and high (HDLc) density lipoprotein cholesterol, triglycerides and glycosylated hemoglobin A1C in whole blood were determined; the presence of proteinuria was determined in partial urine. The eGFR was estimated by equations and the body mass index (BMI) was calculated. Results: The frequency of MS was significantly higher among patients with CKD (eGFR < 60 mL/min/m2), mildly reduced eGFR (60-89 mL/min/m2), hyperfiltration or proteinuria. The risks of mildly reduced eGFR and protenuria were significantly associated with elevated fasting blood glucose, low HDLc and MS, with and without adjustment for sex, age and BMI. When adjusted for the diabetic condition, only the risk of proteinuria remained associated with MS and elevated blood pressure. The risk of hyperfiltration was not associated with MS. Conclusion: The reduction in estimated glomerular function and proteinuria were associated with MS and its individual components. Other studies that confirm the results are required. Introducción: La relación del síndrome metabólico (SM) y sus componentes con la tasa de filtración glomerular y proteinuria aun no está ampliamente dilucidada. El objetivo del trabajo fue asociar la tasa de filtración glomerular estimada (TFGe) y la proteinuria con el SM y sus componentes individuales en adultos con factores de riesgo cardiometabólico, que acudieron a un centro de salud público ubicado en el municipio San Diego, Estado Carabobo-Venezuela. Métodos: Estudio descriptivo-transversal (n=176 pacientes). Se midió peso, talla, circunferencia de cintura, porcentaje de grasa corporal y presión arterial; se determinó en suero glucosa, creatinina, urea, nitrógeno ureico, colesterol total, colesterol unido a lipoproteínas de baja (LDLc) y alta (HDLc) densidad, triglicéridos y hemoglobina glicosilada A1C en sangre total; en orina parcial se determinó la presencia de proteinuria. Se estimó la TFGe por ecuaciones y se calculó el índice de masa corporal (IMC). Resultados: La frecuencia de SM fue más elevada en pacientes con enfermedad crónica renal (TFGe < 60 mL/min/m2), TFGe ligeramente disminuida (60-89 mL/min/m2), hiperfiltración o proteinuria. Los riesgos de disminución ligera de la TFGe y proteinuria se asociaron significativamente a SM, glicemia elevada y HDLc bajo, con y sin ajuste por sexo, edad e IMC. Cuando se ajustó por condición de diabético, el riesgo de proteinuria se asoció a SM y presión arterial elevada. El riesgo de hiperfiltración no se asoció a SM. Conclusión: La reducción de la TGFe y la proteinuria se asociaron al SM y sus componentes individuales. Se requieren otros estudios que confirmen los resultados. Introdução: A relação da síndrome metabólica (SM) e seus componentes com a taxa de filtração glomerular e proteinúria ainda não está amplamente elucidada. O objetivo foi associar a taxa de filtração glomerular estimada (TFGe) e proteinúria com a SM e seus componentes individuais em adultos com fatores de risco cardiometabólico, que atendidos em um centro de saúde pública localizada no município San Diego, Carabobo -Venezuela. Métodos: Estudo descritivo-transversal (n = 176 pacientes). Peso, altura, circunferência da cintura, percentual de gordura corporal e pressão arterial foram medidos; foram determinada em soro glicose, creatinina, ureia, azoto da ureia, colesterol total, colesterol de lipoproteína de baixa (LDLc) e alta densidade (HDLc), triglicerídeos e hemoglobina glicada A1C em sangue total; a presença de proteinúria foi determinada em urina parcial,. A TFG foi estimada por equações e o índice de massa corporal (IMC) foi calculado. Resultados: A frequência de SM foi maior em pacientes com doença renal crônica (TFGe <60 mL/min/m2), TFGe discretamente diminuída (60-89 mL/min/m2), hiperfiltração ou proteinúria. Os riscos de uma ligeira diminuição na TFGe e proteinúria foram significativamente associados à SM, glicose sérica alta e HDLc baixo, com e sem ajuste para sexo, idade e IMC. Quando ajustado para a condição diabética, o risco de proteinúria estava associado à SM e à hipertensão. O risco de hiperfiltração não foi associado à SM. Conclusão: A redução de TGFe e proteinúria foram associaram à SM e seus componentes individuais. Outros estudos devem confirmar os resultados. Universidad Nacional Cba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología 2019-08-29 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf text/html https://revistas.unc.edu.ar/index.php/med/article/view/23677 Revista de la Facultad de Ciencias Médicas de Córdoba.; Vol. 76 No. 3 (2019); 135-141 Revista de la Facultad de Ciencias Médicas de Córdoba; Vol. 76 Núm. 3 (2019); 135-141 Revista da Faculdade de Ciências Médicas de Córdoba; v. 76 n. 3 (2019); 135-141 1853-0605 0014-6722 10.31053/1853.0605.v76.n3 spa https://revistas.unc.edu.ar/index.php/med/article/view/23677/24347 https://revistas.unc.edu.ar/index.php/med/article/view/23677/24551 Derechos de autor 2019 Universidad Nacional de Córdoba |