Positive correlation between proteasome activity and polyphenols in the telencephalon of adult female mice

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Introduction: Proteasome regulates proteostasis, and can be compromised in neurodegenerative diseases. Thus, our aim was to correlate the activity of proteasome to the level of polyphenols in telencephalon during murine adulthood. Methods: Proteasome activity, polyphenols and other variables (glucos...

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Autores principales: Miranda, Agustín Ramiro, Cortez, Mariela Valentina, Serra, Silvana Valeria, Soria, Elio Andres
Formato: Artículo revista
Lenguaje:Inglés
Publicado: Universidad Nacional Cba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología 2018
Materias:
central nervous system
aging
proteostasis
phytochemicals
multivariate statistics
sistema nervioso central
envejecimiento
fitoquímicos
estadística multivariada.
Acceso en línea:https://revistas.unc.edu.ar/index.php/med/article/view/19930
Aporte de:
Revistas de la UNC de Universidad Nacional de Córdoba
id I10-R10-article-19930
record_format ojs
institution Universidad Nacional de Córdoba
institution_str I-10
repository_str R-10
container_title_str Revistas de la UNC
language Inglés
format Artículo revista
topic central nervous system
aging
proteostasis
phytochemicals
multivariate statistics
sistema nervioso central
envejecimiento
proteostasis
fitoquímicos
estadística multivariada.
spellingShingle central nervous system
aging
proteostasis
phytochemicals
multivariate statistics
sistema nervioso central
envejecimiento
proteostasis
fitoquímicos
estadística multivariada.
Miranda, Agustín Ramiro
Cortez, Mariela Valentina
Serra, Silvana Valeria
Soria, Elio Andres
Positive correlation between proteasome activity and polyphenols in the telencephalon of adult female mice
topic_facet central nervous system
aging
proteostasis
phytochemicals
multivariate statistics
sistema nervioso central
envejecimiento
proteostasis
fitoquímicos
estadística multivariada.
author Miranda, Agustín Ramiro
Cortez, Mariela Valentina
Serra, Silvana Valeria
Soria, Elio Andres
author_facet Miranda, Agustín Ramiro
Cortez, Mariela Valentina
Serra, Silvana Valeria
Soria, Elio Andres
author_sort Miranda, Agustín Ramiro
title Positive correlation between proteasome activity and polyphenols in the telencephalon of adult female mice
title_short Positive correlation between proteasome activity and polyphenols in the telencephalon of adult female mice
title_full Positive correlation between proteasome activity and polyphenols in the telencephalon of adult female mice
title_fullStr Positive correlation between proteasome activity and polyphenols in the telencephalon of adult female mice
title_full_unstemmed Positive correlation between proteasome activity and polyphenols in the telencephalon of adult female mice
title_sort positive correlation between proteasome activity and polyphenols in the telencephalon of adult female mice
description Introduction: Proteasome regulates proteostasis, and can be compromised in neurodegenerative diseases. Thus, our aim was to correlate the activity of proteasome to the level of polyphenols in telencephalon during murine adulthood. Methods: Proteasome activity, polyphenols and other variables (glucose and hydroperoxides) were analysed in Balb/c female telencephala (n = 20, age = 4-12 months), using multivariate methods. Results: The following values were found: proteasome activity = 3.1 ± 0.6 FI/µg of tissue proteins, glucose = 0.1 ± 0.0 µg/µg, hydroperoxides = 363.4 ± 96.6 OD/µg, and polyphenols = 0.1 ± 0.0 ng/µg. Polyphenols reduced during aging showed a direct correlation with proteasome (Pearson’s coefficient = 0.43, p = 0.0590, and a multivariate linear regressive coefficient = 17.85, p = 0.0216), with glucose and hydroperoxides being not involved (p>0.1). This correlation was confirmed by partial least square regression (beta = 0.67). Conclusion: Proteasome activity can be affected during ageing, and promoted by telencephalic polyphenol levels. Thus, these diet compounds might exert benefits in adult brain.
publisher Universidad Nacional Cba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología
publishDate 2018
url https://revistas.unc.edu.ar/index.php/med/article/view/19930
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AT serrasilvanavaleria positivecorrelationbetweenproteasomeactivityandpolyphenolsinthetelencephalonofadultfemalemice
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spelling I10-R10-article-199302019-05-20T10:38:52Z Positive correlation between proteasome activity and polyphenols in the telencephalon of adult female mice Correlación positiva entre la actividad proteasomal y los polifenoles en el telencéfalo de ratones hembras adultas Miranda, Agustín Ramiro Cortez, Mariela Valentina Serra, Silvana Valeria Soria, Elio Andres central nervous system aging proteostasis phytochemicals multivariate statistics sistema nervioso central envejecimiento proteostasis fitoquímicos estadística multivariada. Introduction: Proteasome regulates proteostasis, and can be compromised in neurodegenerative diseases. Thus, our aim was to correlate the activity of proteasome to the level of polyphenols in telencephalon during murine adulthood. Methods: Proteasome activity, polyphenols and other variables (glucose and hydroperoxides) were analysed in Balb/c female telencephala (n = 20, age = 4-12 months), using multivariate methods. Results: The following values were found: proteasome activity = 3.1 ± 0.6 FI/µg of tissue proteins, glucose = 0.1 ± 0.0 µg/µg, hydroperoxides = 363.4 ± 96.6 OD/µg, and polyphenols = 0.1 ± 0.0 ng/µg. Polyphenols reduced during aging showed a direct correlation with proteasome (Pearson’s coefficient = 0.43, p = 0.0590, and a multivariate linear regressive coefficient = 17.85, p = 0.0216), with glucose and hydroperoxides being not involved (p>0.1). This correlation was confirmed by partial least square regression (beta = 0.67). Conclusion: Proteasome activity can be affected during ageing, and promoted by telencephalic polyphenol levels. Thus, these diet compounds might exert benefits in adult brain. Introducción: El proteasoma regula la proteostasis y puede verse comprometido en enfermedades neurodegenerativas. Por lo tanto, nuestro objetivo fue correlacionar la actividad del proteasoma con el nivel de polifenoles en el telencéfalo durante la edad adulta de ratones. Métodos: Se analizaron la actividad del proteasoma, polifenoles y otras variables (glucosa e hidroperóxidos) en telencéfalos de ratones hembras Balb/c (n = 20, edad = 4-12 meses), utilizando métodos multivariados. Resultados: Se encontraron los siguientes valores: actividad proteasomal = 3,1 ± 0,6 FI/?g de proteínas tisulares, glucosa = 0,1 ± 0,0 ?g/?g, hidroperóxidos = 363,4 ± 96,6 OD/?g y polifenoles = 0,1±0,0 ng/?g. Los polifenoles reducidos durante el envejecimiento mostraron una correlación directa con el proteasoma (coeficiente de Pearson = 0,43, p=0,0590 y un coeficiente de regresión lineal multivariante = 17,85, p=0,0216). Glucosa e hidroperóxidos no estuvieron implicados (p>0,1). Esta correlación fue confirmada por regresión parcial de mínimos cuadrados (beta = 0,67). Conclusión: La actividad proteasomal puede afectarse durante el envejecimiento y ser promovida por el nivel telencefálico de polifenoles. Así, estos compuestos dietéticos podrían ser beneficiosos para el cerebro adulto.  Universidad Nacional Cba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología 2018-09-02 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion experimental application/pdf application/vnd.openxmlformats-officedocument.wordprocessingml.document image/jpeg image/tiff image/tiff application/vnd.openxmlformats-officedocument.spreadsheetml.sheet application/vnd.openxmlformats-officedocument.spreadsheetml.sheet https://revistas.unc.edu.ar/index.php/med/article/view/19930 Revista de la Facultad de Ciencias Médicas de Córdoba.; Vol. 75 No. 3 (2018); 189-193 Revista de la Facultad de Ciencias Médicas de Córdoba; Vol. 75 Núm. 3 (2018); 189-193 Revista da Faculdade de Ciências Médicas de Córdoba; v. 75 n. 3 (2018); 189-193 1853-0605 0014-6722 10.31053/1853.0605.v75.n3 eng https://revistas.unc.edu.ar/index.php/med/article/view/19930/21031 https://revistas.unc.edu.ar/index.php/med/article/view/19930/26888 https://revistas.unc.edu.ar/index.php/med/article/view/19930/26889 https://revistas.unc.edu.ar/index.php/med/article/view/19930/26890 https://revistas.unc.edu.ar/index.php/med/article/view/19930/26891 https://revistas.unc.edu.ar/index.php/med/article/view/19930/26892 https://revistas.unc.edu.ar/index.php/med/article/view/19930/26893 Derechos de autor 2018 Universidad Nacional de Córdoba

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