Evaluation of equations using cystatin C for estimation of the glomerular filtration rate in healthy adult population of canidates for kidney donors.

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The determination of the glomerular filtration rate (GFR) is critical for the selection of potential kidney donors. Methods of measurement of GFR are impractical and complex, which led to development of equations to estimate GFR. Objective: To evaluate of the performance of Creatinine and Cystatin C...

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Autor principal: Medina Arnaudo, Gisel Ivana
Formato: Artículo revista
Lenguaje:Español
Publicado: Universidad Nacional Cba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología 2017
Materias:
cistatina C
estimación del Índice de Filtrado Glomerular
donantes renales
cystatin C
estimation of Glomerular Filtration Rate
kidney donors
Acceso en línea:https://revistas.unc.edu.ar/index.php/med/article/view/14814
Aporte de:
Revistas de la UNC de Universidad Nacional de Córdoba
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institution Universidad Nacional de Córdoba
institution_str I-10
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container_title_str Revistas de la UNC
language Español
format Artículo revista
topic cistatina C
estimación del Índice de Filtrado Glomerular
donantes renales
cystatin C
estimation of Glomerular Filtration Rate
kidney donors
spellingShingle cistatina C
estimación del Índice de Filtrado Glomerular
donantes renales
cystatin C
estimation of Glomerular Filtration Rate
kidney donors
Medina Arnaudo, Gisel Ivana
Evaluation of equations using cystatin C for estimation of the glomerular filtration rate in healthy adult population of canidates for kidney donors.
topic_facet cistatina C
estimación del Índice de Filtrado Glomerular
donantes renales
cystatin C
estimation of Glomerular Filtration Rate
kidney donors
author Medina Arnaudo, Gisel Ivana
author_facet Medina Arnaudo, Gisel Ivana
author_sort Medina Arnaudo, Gisel Ivana
title Evaluation of equations using cystatin C for estimation of the glomerular filtration rate in healthy adult population of canidates for kidney donors.
title_short Evaluation of equations using cystatin C for estimation of the glomerular filtration rate in healthy adult population of canidates for kidney donors.
title_full Evaluation of equations using cystatin C for estimation of the glomerular filtration rate in healthy adult population of canidates for kidney donors.
title_fullStr Evaluation of equations using cystatin C for estimation of the glomerular filtration rate in healthy adult population of canidates for kidney donors.
title_full_unstemmed Evaluation of equations using cystatin C for estimation of the glomerular filtration rate in healthy adult population of canidates for kidney donors.
title_sort evaluation of equations using cystatin c for estimation of the glomerular filtration rate in healthy adult population of canidates for kidney donors.
description The determination of the glomerular filtration rate (GFR) is critical for the selection of potential kidney donors. Methods of measurement of GFR are impractical and complex, which led to development of equations to estimate GFR. Objective: To evaluate of the performance of Creatinine and Cystatin C based equation for estimation of GFR in healthy adult population of candidates for kidney donors. Materials and Methods: a cross-sectional study was performed in 72 adult patients evaluated as candidates for kidney donors. GFR was measured by nonradiolabeled Iothalamate clearence (mGFR). GFR was estimated by the Modification of Diet in Renal Disease (eGFR MDRD) equation, Chronic Kidney Disease Epidemiology Collaboration study (eGFR CKD-EPICREAT, eGFR CKD-EPI-CREAT+CYSC) and the equation proposed by Stevens et al. (STEVENSCREAT+CYSC). The overall performance of all equations was analyzed. Results: eGFR CKD-EPICREAT+CYSC, eGFR STEVENS CREAT+CYSC and eGFR CKD-EPI-CREAT presented lower bias (1,93; - 0,71; -1,53 mL/ min/1,73m2 respectively) compared with eGFR MDRD (bias= -10,36 mL/min/1.73m2). This study demonstrated that the best diagnostic performance was shown by eGFR CKD-EPICREAT+CYSC (LR(+)=9,8; “Positive Likelihood Ratios”), followed by eGFR STEVENSCREAT+CYSC (LR(+)=4,7) and eGFR CKD-EPICREAT (LR(+)=3,7). Discussion: CKD-EPICREAT+CYSC, STEVENS-CREAT+CYSC and CKDEPI-CREAT equations demonstrated a clearly higher performance to estimate GFR compared with MDRD in the study population.
publisher Universidad Nacional Cba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología
publishDate 2017
url https://revistas.unc.edu.ar/index.php/med/article/view/14814
work_keys_str_mv AT medinaarnaudogiselivana evaluationofequationsusingcystatincforestimationoftheglomerularfiltrationrateinhealthyadultpopulationofcanidatesforkidneydonors
AT medinaarnaudogiselivana evaluaciondeecuacionesqueutilizancistatinacparaestimarfiltradoglomerularenadultossanoscandidatosadonantesrenales
first_indexed 2022-08-20T01:24:43Z
last_indexed 2022-08-20T01:24:43Z
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spelling I10-R10-article-148142019-05-20T10:36:47Z Evaluation of equations using cystatin C for estimation of the glomerular filtration rate in healthy adult population of canidates for kidney donors. Evaluación de ecuaciones que utilizan cistatina c para estimar filtrado glomerular en adultos sanos candidatos a donantes renales Medina Arnaudo, Gisel Ivana cistatina C estimación del Índice de Filtrado Glomerular donantes renales cystatin C estimation of Glomerular Filtration Rate kidney donors The determination of the glomerular filtration rate (GFR) is critical for the selection of potential kidney donors. Methods of measurement of GFR are impractical and complex, which led to development of equations to estimate GFR. Objective: To evaluate of the performance of Creatinine and Cystatin C based equation for estimation of GFR in healthy adult population of candidates for kidney donors. Materials and Methods: a cross-sectional study was performed in 72 adult patients evaluated as candidates for kidney donors. GFR was measured by nonradiolabeled Iothalamate clearence (mGFR). GFR was estimated by the Modification of Diet in Renal Disease (eGFR MDRD) equation, Chronic Kidney Disease Epidemiology Collaboration study (eGFR CKD-EPICREAT, eGFR CKD-EPI-CREAT+CYSC) and the equation proposed by Stevens et al. (STEVENSCREAT+CYSC). The overall performance of all equations was analyzed. Results: eGFR CKD-EPICREAT+CYSC, eGFR STEVENS CREAT+CYSC and eGFR CKD-EPI-CREAT presented lower bias (1,93; - 0,71; -1,53 mL/ min/1,73m2 respectively) compared with eGFR MDRD (bias= -10,36 mL/min/1.73m2). This study demonstrated that the best diagnostic performance was shown by eGFR CKD-EPICREAT+CYSC (LR(+)=9,8; “Positive Likelihood Ratios”), followed by eGFR STEVENSCREAT+CYSC (LR(+)=4,7) and eGFR CKD-EPICREAT (LR(+)=3,7). Discussion: CKD-EPICREAT+CYSC, STEVENS-CREAT+CYSC and CKDEPI-CREAT equations demonstrated a clearly higher performance to estimate GFR compared with MDRD in the study population. Resumen: La valoración del Índice de Filtrado Glomerular (IFG) es fundamental para la selección de potenciales donantes renales. Para su medición existen métodos poco prácticos y complejos, por lo cual se han desarrollado ecuaciones de estimación del IFG. Objetivo: Evaluar el rendimiento diagnóstico de ecuaciones de estimación del IFG a partir de Creatinina y Cistatina C en una población de adultos sanos candidatos a donantes renales. Materiales y métodos: Se llevó a cabo un estudio transversal en 72 pacientes de ambos sexos de entre 18 y 75 años de edad, candidatos a donantes renales. Se les midió el IFG a través del clearance de Iotalamato no marcado (IFGm). Se evaluaron cuatro ecuaciones de estimación del FG (IFGe): MDRD, del estudio “Modification of Diet in Renal Disease”; CKD-EPI-Creatinina (CKD-EPI-CREAT) y CKD-EPI-Creatinina y Cistatina C (CKD-EPI-CREAT+CIS), desarrolladas por el grupo “Chronic Kidney Disease Epidemiology Collaboration”; y la que incluye Creatinina y Cistatina C propuesta por Stevens y col. (STEVENS-CREAT+CIS). Se analizó el desempeño de cada ecuación con respecto al IFGm. Resultados: Las ecuaciones CKD-EPI-CREAT+CIS, STEVENS-CREAT+CIS y CKD-EPI-CREAT mostraron ser más exactas (bias= 1,93; -0,71; -1,53 mL/min/1,73m2 respectivamente) que MDRD (bias= -10,36 mL/min/1,73m2). El mejor rendimiento diagnóstico lo mostró  el IFGe CKD-EPI-CREAT+CIS (LR(+)=9,8; “Positive Likelihood Ratios”), seguido por IFGe STEVENS-CREAT+CIS (LR(+)=4,7) y luego por IFGe CKD-EPI-CREAT (LR(+)=3,7). Discusión: Las ecuaciones CKD-EPI-CREAT+CIS, STEVENS-CREAT+CIS y CKD-EPI-CREAT demostraron tener un desempeño claramente superior a MDRD para estimar el IFG en la población estudiada. Universidad Nacional Cba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología 2017-09-08 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf application/vnd.openxmlformats-officedocument.wordprocessingml.document application/vnd.openxmlformats-officedocument.wordprocessingml.document application/vnd.openxmlformats-officedocument.wordprocessingml.document application/vnd.openxmlformats-officedocument.wordprocessingml.document image/jpeg image/jpeg image/jpeg https://revistas.unc.edu.ar/index.php/med/article/view/14814 Revista de la Facultad de Ciencias Médicas de Córdoba.; Vol. 74 No. 3 (2017); 243-250 Revista de la Facultad de Ciencias Médicas de Córdoba; Vol. 74 Núm. 3 (2017); 243-250 Revista da Faculdade de Ciências Médicas de Córdoba; v. 74 n. 3 (2017); 243-250 1853-0605 0014-6722 10.31053/1853.0605.v74.n3 spa https://revistas.unc.edu.ar/index.php/med/article/view/14814/19253 https://revistas.unc.edu.ar/index.php/med/article/view/14814/26106 https://revistas.unc.edu.ar/index.php/med/article/view/14814/26107 https://revistas.unc.edu.ar/index.php/med/article/view/14814/26108 https://revistas.unc.edu.ar/index.php/med/article/view/14814/26109 https://revistas.unc.edu.ar/index.php/med/article/view/14814/26110 https://revistas.unc.edu.ar/index.php/med/article/view/14814/26111 https://revistas.unc.edu.ar/index.php/med/article/view/14814/26112 Derechos de autor 2017 Universidad Nacional de Córdoba

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