Production of aromatic α-hydroxyacids by epimastigotes of Trypanosoma cruzi, and its possible role in NADH reoxidation
Epimastigotes of Trypanosoma cruzi in culture produce and excrete into the medium small amounts of phenyllactic acid and p-hydrocyphenyllactic acids, presumbly arising from the catabolism of the aromatic amino acids phenylalanine and tyrosine, respectively. This production might constitute a minor p...
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| Otros Autores: | , , |
| Formato: | Capítulo de libro |
| Lenguaje: | Inglés |
| Publicado: |
1994
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| Materias: | |
| Acceso en línea: | Registro en Scopus Handle Registro en la Biblioteca Digital |
| Aporte de: | Registro referencial: Solicitar el recurso aquí |
| Sumario: | Epimastigotes of Trypanosoma cruzi in culture produce and excrete into the medium small amounts of phenyllactic acid and p-hydrocyphenyllactic acids, presumbly arising from the catabolism of the aromatic amino acids phenylalanine and tyrosine, respectively. This production might constitute a minor pathway for the reoxidation of cytosolic NADH, through the concerted action of tyrosine aminotransferase and aromatic α-hydroxyacid dehydrogenase. © 1994. |
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| Bibliografía: | Stibbs, Seed, Metabolism of tyrosine and phenylalanine in Trypanosoma brucei gambiense (1975) Int. J. Biochem., 6, pp. 197-203 Stibbs, Seed, Further studies on the metabolism of tryptophan in Trypanosoma brucei gambiense: cofactors, inhibitors, and endproducts (1975) Experientia, 31, pp. 274-277 Stibbs, Seed, Short-term metabolism of [14C] tryptophan in rats infected with Trypanosoma brucei gambiense (1975) J. Infect. Dis., 131, pp. 459-462 Nowicki, Montemartini, Duschak, Santomé, Cazzulo, Presence and subcellular localization of tyrosine aminotransferase and p-hydroxyphenyl lactate dehydrogenase n epimastigotes of Trypanosoma cruzi (1992) FEMS Microbiol. Lett., 92, pp. 119-124 Montemartini, Santomé, Cazzulo, Nowicki, Purification and partial structural and kinetic characterization of tyrosine aminotransferase from epimastigotes of Trypanosoma cruzi (1993) Biochem. J., 292, pp. 901-906 Cazzulo, Franke de Cazzulo, Engel, Cannata, End products and enzyme levels of aerobic glucose fermentation in Trypanosomatids (1985) Mol. Biochem. Parasitol., 16, pp. 329-343 Cazzulo, The aerobic fermentation of glucose by Trypanosomatids (1992) FASEB J., 6, pp. 3153-3161 Engel, Frank de Cazzulo, Stoppani, Cannata, Cazzulo, Aerobic glucose fermentation by Trypanosoma cruzi axenic culture amastigote-like forms growth and diffentiation to epimastigotes (1987) Mol. Biochem. Parasitol., 26, pp. 1-10 |
| ISSN: | 03781097 |