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  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  type of resource: text
  abstract: Galactofuranosyl units (Galf), mainly in the β-configuration, are constituents of infectious microorganisms, such as the Mycobacteria, trypanosomatids like Trypanosoma cruzi and Leishmania, and fungi like Aspergillus fumigatus. The metabolic pathways involved in the biosynthesis of the microbial glycoconjugates containing Galf are attractive targets for the development of therapeutic agents, because Galf is absent in mammalian cells. The enzymes involved in the biosynthesis of Galf-containing molecules are the UDP-galactopyranosyl mutase, which catalyzes the interconversion of UDP-Galp into UDP-Galf, the donor of Galf units, and the galactofuranosyltransferases, which are responsible for the incorporation of the sugar into the glycoconjugates. In some species, β-D-galactofuranosidases have been identified as responsible for the degradation of the D-Galf containing glycoconjugates. Although the metabolism of β-D-galactofuranosides has been extensively studied, the α-D-Galf biosynthetic and metabolic machinery still remain unclear. The description of the enzymes involved in its metabolism is important, considering that glycoconjugates containing α-D-Galf residues have been also described in several pathogenic microorganisms including bacteria, such as Escherichia coli and Streptococcus pneumoniae, and fungi, such as Paracoccidioides brasiliensis, the causative agent of paracoccidioidomycosis. It is interesting that in the latter Galf is present in both anomeric configurations. Recent methods for the synthesis of galactofuranosides are included in this chapter. © 2012 by Nova Science Publishers, Inc. All rights reserved.
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  note: openaire Política editorial
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title info:
  title: Glycans: Biochemistry, Characterization and Applications
title info:
  title: Glycans: Biochem., Charact. and Appl
origin info:
  publisher: Nova Science Publishers, Inc., 2012
physical description:
  extent: pp. 207-268

record content source: Scopus
record creation date: 190411
record change date: 20230518205511.0
record identifier: PAPER-23487
language of cataloging:
  language term: spa

title: Galactofuranosyl-containing glycans: Occurrence, synthesis and biochemistry

name part: Marino, C.
role:
  role term: creator

name part: Gallo-Rodriguez, C.

name part: de Lederkremer, R.M.

place:
  place term: xx
publisher: Nova Science Publishers, Inc.
date issued: 2012
issuance: monographic

language term: eng