Design, synthesis, and anti‐ Trypanosoma cruzi evaluation of a new class of cell‐growth inhibitors structurally related to Fenoxycarb

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Several compounds, structurally related to the insect‐growth regulator Fenoxycarb (1), were designed and synthesized. These compounds were tested as growth inhibitors of Trypanosoma cruzi cells (epimastigotes). Compounds 6, 16, 18, and 22 were very active against T. cruzi making them promising good...

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Autor principal: Schvartzapel, A.J
Otros Autores: Fichera, L., Esteva, M., Rodriguez, J.B, Gros, E.G
Formato: Capítulo de libro
Lenguaje:Inglés
Publicado: 1995
Acceso en línea:Registro en Scopus
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Biblioteca Central Dr. Luis F. Leloir (FCEN) de Universidad de Buenos Aires
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100 1 |a Schvartzapel, A.J. 
245 1 0 |a Design, synthesis, and anti‐ Trypanosoma cruzi evaluation of a new class of cell‐growth inhibitors structurally related to Fenoxycarb 
260 |c 1995 
270 1 0 |m Gros, E.G.; Departamento de Quimica Orgánica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, 1428 Buenos Aires, Buenos Aires, Argentina 
506 |2 openaire  |e Política editorial 
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504 |a Rodriguez, J.B., Gros, E.G., Stoka, A.M., Synthesis and Activity of Juvenile Hormone Analogues (JHA), Part II (1989) Zeitschrift für Naturforschung B, 44, p. 983 
504 |a Perlawagora‐Szumlewicz, A., Petana, W.P., Figueiredo, M.J., (1975) Rev. Inst. Med. Trop., 17, p. 97 
504 |a Stoka, A.M., Rivas, C., Segura, E.L., Rodriguez, J.B., Gros, E.G., (1990) Z. Naturforsch., B, 45, p. 96 
504 |a Rodriguez, J.B., Gros, E.G., Stoka, A.M., (1991) BioMed. Chem. Lett., 1, p. 679 
504 |a Vladusic, E.A., Bussmann, L.E., Visconti, P.E., Stoka, A.M., Rodriguez, J.B., Gros, E.G., Charreau, E.H., (1994) J. Steroid Biochem. Mol. Biol., 50, p. 181 
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504 |a Johnstone, R.A.W., Rose, M.E., (1979) Tetrahedron, 75, p. 2169 
504 |a Dorman, D.E., Jautelat, M., Roberts, J.D., (1971) J. Org. Chem., 36, p. 2757 
504 |a Friedel, R.A., Retcofsky, H.L., (1963) J. Am. Chem. Soc., 85, p. 1300 
504 |a Breitmaier, E., Voelter, W., (1987) Carbon‐13 NMR Spectroscopy, , VCH, New York 
504 |a Pretsch, E., Clerc, T., Seibel, J., Simon, W., (1976) Tabellen zur Strukturaufklärung Organischer Verbindungen mit Spektroskopischen Methoden, , Springer Verlag, Heidelberg 
504 |a Brown, H.C., (1975) Organic Syntheses via Boranes, p. 18. , John Wiley, New York 
504 |a Zweifel, G., Brown, H.C., (1963) Org. React., 13, p. 1 
504 |a Brown, H.C., (1961) Tetrahedron, 12, p. 117 
504 |a Fieser, L.F., Herz, J.E., Klohs, M.W., Romero, M.A., Utne, T., (1952) J. Am. Chem. Soc., 74, p. 3309 
504 |a Agarwal, K.L., Khorana, H.G., (1972) J. Am. Chem. Soc., 94, p. 3758 
504 |a March, J., (1992) Advanced Organic Chemistry, , Wiley, New York 
504 |a Scrimin, P., Tecilla, P., Tonellato, U., (1992) J. Am. Chem. Soc., 114, p. 5086 
504 |a Freeman, F., Kim, D.S.H.L., Rodriguez, E., (1992) J. Org. Chem., 57, p. 1722 
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520 3 |a Several compounds, structurally related to the insect‐growth regulator Fenoxycarb (1), were designed and synthesized. These compounds were tested as growth inhibitors of Trypanosoma cruzi cells (epimastigotes). Compounds 6, 16, 18, and 22 were very active against T. cruzi making them promising good candidates either for blood‐bank sterilization of Chagas'‐disease surveillance, while compounds 11, 12, 13, and 19 showed a moderate degree of activity. Copyright © 1995 Verlag GmbH & Co. KGaA, Weinheim  |l eng 
593 |a Departamento de Quimica Orgánica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, 1428 Buenos Aires, Buenos Aires, Argentina 
593 |a Instituto Nacional de Investigación de la Enfermedad de Chagas ), Paseo Colón 568, 1063 Buenos Aires, Colón, Buenos Aires, Argentina 
690 1 0 |a CARBAMIC ACID DERIVATIVE 
690 1 0 |a FENOXYCARB 
690 1 0 |a INSECTICIDE 
690 1 0 |a ARTICLE 
690 1 0 |a DRUG ACTIVITY 
690 1 0 |a DRUG DESIGN 
690 1 0 |a DRUG SYNTHESIS 
690 1 0 |a NONHUMAN 
690 1 0 |a NUCLEAR MAGNETIC RESONANCE 
690 1 0 |a REACTION ANALYSIS 
690 1 0 |a TRYPANOSOMA CRUZI 
700 1 |a Fichera, L. 
700 1 |a Esteva, M. 
700 1 |a Rodriguez, J.B. 
700 1 |a Gros, E.G. 
773 0 |d 1995  |g v. 78  |h pp. 1207-1214  |k n. 5  |p Helv. Chim. Acta  |x 0018019X  |w (AR-BaUEN)CENRE-1771  |t Helvetica Chimica Acta 
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856 4 0 |u https://doi.org/10.1002/hlca.19950780513  |y DOI 
856 4 0 |u https://hdl.handle.net/20.500.12110/paper_0018019X_v78_n5_p1207_Schvartzapel  |y Handle 
856 4 0 |u https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0018019X_v78_n5_p1207_Schvartzapel  |y Registro en la Biblioteca Digital 
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962 |a info:eu-repo/semantics/article  |a info:ar-repo/semantics/artículo  |b info:eu-repo/semantics/publishedVersion 
999 |c 73451 

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