Tabla de Contenidos:
  • General principles
  • 1 Historical background and overview
  • 2 Monosaccharide diversity
  • 3 Oligosaccharides and polysaccharides
  • 4 Cellular organization of glycosylation
  • 5 Glycosylation precursors
  • 6 Glycosyltransferases and glycan-processing enzymes
  • 7 Biological functions of glycans
  • 8 A genomic view of glycobiology
  • Structure and Biosynthesis
  • 9 N-glycans
  • 10 O-GalNAc glycans
  • 11 Glycosphingolipids
  • 12 Glycosylphosphatidylinositol anchors
  • 13 Other classes of eukaryotic glycans
  • 14 Structures common to different glycans
  • 15 Sialic acids and other nonulosonic acids
  • 16 Hyaluronan
  • 17 Proteoglycans and sulfated glycosaminoglycans
  • 18 Nucleocytoplasmic glycosylation
  • 19 The O-GlcNAc modification
  • Glycans in Evolution and Development
  • 20 Evolution of glycan diversity
  • 21 Eubacteria
  • 22 Archaea
  • 23 Fungi
  • 24 Viridiplantae and algae
  • 25 Nematoda
  • 26 Arthropoda
  • 27 Deuterostomes
  • Glycan-Binding Proteins
  • 28 Discovery and classification of glycan-binding proteins
  • 29 Principles of glycan recognition
  • 30 Structural biology of glycan recognition
  • 31 R-type lectins
  • 32 L-type lectins
  • 33 P-type lectins
  • 34 C-type lectins
  • 35 I-type lectins
  • 36 Galectins
  • 37 Microbial lectins: hemagglutinins, adhesins, and toxins
  • 38 Proteins that bind sulfated glycosaminoglycans
  • Glycans in Physiology and Disease
  • 39 Glycans in glycoprotein quality control
  • 40 Free glycans as bioactive molecules
  • 41 Glycans in systemic physiology
  • 42 Bacterial and viral infections
  • 43 Parasitic infections
  • 44 Genetic disorders of glycan degradation
  • 45 Congenital disorders of glycosylation
  • 46 Glycans in acquired human diseases
  • 47 Glycosylation changes in cancer
  • Methods and a Applications
  • 48 Glycan-recognizing probes as tools
  • 49 Glycosylation mutants of cultured mammalian cells
  • 50 Structural analysis of glycans
  • 51 Glycomics and glycoproteomics
  • 52 Glycoinformatics
  • 53 Chemical synthesis of glycans and glycoconjugates
  • 54 Chemoenzymatic synthesis of glycans and glycoconjugates
  • 55 Chemical tools for inhibiting glycosylation
  • 56 Glycosylation engineering
  • 57 Glycans in biotechnology and the pharmaceutical industry
  • 58 Glycans in nanotechnology
  • 59 Glycans in bioenergy and materials science
  • 60 Future directions in glycosciences