Novel sulfated xylogalactoarabinans from green seaweed Cladophorafalklandica chemical structure and action on the fibrin network
The water-soluble sulfated xylogalactoarabinans from green seaweed Cladophora falklandica are consti-tuted by a backbone of 4-linked Beta -l-arabinopyranose units partially sulfated mainly on C3 and also onC2. Besides, partial glycosylation mostly on C2 with single stubs of Beta-d-xylopyranose, or s...
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| Otros Autores: | , , , |
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| Formato: | Artículo |
| Lenguaje: | Inglés |
| Materias: | |
| Acceso en línea: | http://ri.agro.uba.ar/files/intranet/articulo/2016arata.pdf LINK AL EDITOR |
| Aporte de: | Registro referencial: Solicitar el recurso aquí |
| Sumario: | The water-soluble sulfated xylogalactoarabinans from green seaweed Cladophora falklandica are consti-tuted by a backbone of 4-linked Beta -l-arabinopyranose units partially sulfated mainly on C3 and also onC2. Besides, partial glycosylation mostly on C2 with single stubs of Beta-d-xylopyranose, or single stubs of Beta-d-galactofuranose or short chains comprising (1 flecha 5)- and/or (1 flecha 6)-linkages, was also found. These compounds showed anticoagulant activity, although much lower than that of heparin. The effect of a puri-fied fraction (F1) on the fibrin network was studied in detail. It modifies the kinetics of fibrin formation,suggesting an impaired polymerization process. Scanning electron microscopy showed a laxer confor-mation, with larger interstitial pores than the control. Accordingly, this network was lysed more easily. These fibrin properties would reduce the time of permanence of the clot in the blood vessel, inducing alesser thrombogenic state. One of the possible mechanisms of its anticoagulant effect is direct thrombininhibition. |
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| ISSN: | 0144-8617 |